Objective:To investigate the correlation between serum free prostate specific antigen (F-PSA), prostate specific antigen (PSA), human growth hormone (HGH) and carbohydrate antigen 15-3 (CA15-3) levels and postoperative metastasis in patients with breast cancer. Methods: One hundred cases of breast malignant tumors admitted to our hospital were enrolled in this study. The levels ofserum F-PSA, PSA, HGH and CA15-3 were measured before treatment. The patients were followed-up for 7 to 24 months after surgery-assisted chemotherapy and radiotherapy. The levels of serum F-PSA, PSA, HGH and CA15-3were compared between patients in the metastatic group and in the non-metastatic group. Results:There were 44 patients with postoperative metastases and 56 patients without postoperative metastases during the longest follow-up of 24 months after operation, and the incidence of metastasis was 44%. The levels of serum F-PSA, PSA, HGH and CA15-3 in the postoperative metastasis group were higher than those in the non-metastasis group (P<0.05). Compared with each individual test, the sensitivity, specificity, accuracy, positive predictive value and negative predictive value of combined detection of F-PSA, PSA, HGH and CA15-3 in predicting breast cancer metastasis after operation increased. Conclusion: The serum F-PSA,PSA,HGH and CA15-3 can be used as important tumor markers for predicting postoperative metastasis of breast cancer. |