Objective:To investigate the effect of ginkgo-dipyridamole combined with acupuncture on the recovery of neural function in patients with traumatic brain injury(TBI).Methods:A total of 80 patients with TBI treated from March 2017 to March 2018 were selected as research objects and were divided into control group and treatment group according to the random number table method(n=44, each). The two groups were given routine treatment of western medicine, the control group was given treatment of acupuncture(1 time a day) on top ofthe routine treatment, and the treatment group was giventreatment of ginkgo-dipyridamole injection combined with acupuncture on top of the routine treatment. The two groups were treated for 14 days continuously.The levels of serum nerve growth factor(NGF), brain-derived neurotrophic factor(BDNF), tumor necrosis factor-α(TNF-α), interleukin-4(IL-4), interleukin-8(IL-8) were compared between the two groups before treatment and 7 days, 14 days after treatment. The scores of Fugl-Meyer assessment(FMA), glasgow coma scale(GCS), and national instiutes of health stroke scale(NIHSS) were compared between two groups before treatment and 14 days, 20 days after the treatment.Results:There were no significant differences in all observation indexes between the two groups before treatment(P>0.05). 7 days and 14 days after treatment, the levels of serum NGF and BDNF in the two groups were higher than those before treatment(P<0.01), and the levels of serum NGF and BDNF in the treatment group were higher than those in the control group significantly(P<0.01). 7 days and 14 days after treatment, the levels of serum IL-4 and IL-8 in the control group were lower than those before treatment(P<0.05 or P<0.01). 7 days and 14 days after treatment, the levels of serum TNF-α, IL-4 and IL-8 in the treatment group were lower than those before treatment(P<0.01). 7 days after treatment, the levels of serum TNF-α and IL-8 in the treatment group were lower than those in the control group(P<0.05 or P<0.01). 14 days after treatment, the levels of serum TNF-α, IL-4 and IL-8 in the treatment group were lower than those in control group(P<0.05 or P<0.01). 14 days and 20 days after treatment, the scores of FMA and GCS in the two groups were higher than those before treatment(P<0.01), while the scores of NIHSS the were lower than those before treatment(P<0.01). 14 days and 20 days after treatment, the scores of FMA and GCS in treatment group were higher than those in the control group(P<0.01), and the scores of NIHSS in treatment group were lower than those in control group(P<0.01).Conclusion:Ginkgo-dipyridamole combined with acupuncture in the treatment of TBI can promote the recovery of nerve function, reduce inflammatory reaction, improve the comprehensive motor function of patients, and reduce the degree of coma, and the application effect is better than that of acupuncture. |
[1] 程鹏玲, 于春丽, 宋闰宇,等. 依达拉奉联合醒脑静治疗急性脑出血的临床疗效观察[J].现代生物医学进展, 2016, 16(4):751-754.
[2] LI F, CHEN Q X. Risk factors for mental disorders in patients with hypertensive intracerebral hemorrhage following neurosurgical treatment[J].J Neurol Sci, 2014, 341(1-2):128-132.
[3] 林清松, 康德智. 创伤性脑血管损伤[J].中华神经创伤外科电子杂志, 2016, 2(3):178-180.
[4] 林小艳, 白金娥. 银杏达莫联合高压氧治疗高血压脑出血术后的疗效观察[J].安徽医药, 2018, 22(1):156-159.
[5] 方丽萍, 肖展翅, 甘小莉. 针灸足三里治疗中老年脑出血患者院内感染临床研究[J].中医学报, 2016, 31(6):913-915.
[6] 瞿庆庆, 宋张平, 管建军. 针刺联合高压氧治疗运动区颅脑外伤术后偏瘫48例疗效观察[J].河北中医, 2017,39(12):1867-1871.
[7] 陆敏, 张静. 急性脑损伤患者熵指数与格拉斯哥昏迷评分的相关性研究[J].中华危重病急救医学, 2018, 30(1):47-50.
[8] NAESS H, KURTZ M, THOMASSEN L, et al. Serial NIHSS scores in patients with acute cerebral infarction[J].Acta Neurol Scand, 2016, 133(6):415-420.
[9] 徐剑峰, 曾令勇, 刘阳,等. 外伤性脑出血患者术后病原菌感染对神经生长因子及抑瘤素M水平的影响研究[J].中华医院感染学杂志, 2016, 26(8):1755-1757.
[10] 赵东林, 熊超. 中西医结合综合方案治疗脑出血后脑积水临床效果分析[J].四川中医, 2017, 35(9):96-99.
[11] 彭智, 艾文兵. 舒血宁注射液辅助治疗创伤性蛛网膜下腔出血患者的临床观察[J].中国药房, 2016, 27(17):2400-2402.
[12] 陈波, 罗俊超, 王朝阳. 银杏达莫注射液对急性脑梗死患者血清MMP-9和hs-CRP的影响[J].中医药信息, 2016, 33(1):69-71.
[13] 刘晓莹, 邹伟, 于学平. 头穴透刺对脑出血大鼠脑组织中脾酪氨酸激酶表达的影响[J].针灸临床杂志, 2018, 34(2):52-56.
[14] RAPP A E, KRONER J, BAUR S, et al. Analgesia via blockade of NGF/TrkA signaling does not influence fracture healing in mice[J].J Orthop Res, 2015, 33(8):1235-1241.
[15] XU L, NWOSU L N, BURSTON J J, et al. The anti-NGF antibody muMab 911 both prevents and reverses pain behaviour and subchondral osteoclast numbers in a rat model of osteoarthritis pain[J].Osteoarthritis Cartilage, 2016, 24(9):1587-1595.
[16] 李学杰, 黄信全, 莫家鹏,等. 培元还五汤联合康复训练对缺血性脑卒中恢复期患者脑NGF及BDNF蛋白影响分析[J].四川中医, 2017, 35(7):143-145.
[17] 杨成. 银杏达莫联合依达拉奉治疗急性脑梗死的临床疗效观察[J].实用心脑肺血管病杂志, 2016, 24(4):97-99.
[18] 陈燕. 针灸推拿联合康复护理对脑出血患者的疗效研究[J].四川中医, 2017, 35(9):202-204.
[19] ZHOU Y, WANG Y, WANG J, et al. Inflammation in intracerebral hemorrhage:From mechanisms to clinical translation[J].Prog Neurobiol, 2014, 115(2):25-44.
[20] 王强, 孙建怀, 国义民. 创伤性脑出血患者脑组织IL-1β、TNF-α与NF-κB水平变化与其预后的关系分析[J].陕西医学杂志, 2017, 46(12):1653-1654. |