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血清CA125、G-17和血浆D-D、M2-PK四者联合检测在胃癌早期诊断的价值分析
作者:姚海云1  刘伦琴2 
单位:1. 济南市血液供保中心 检验科, 山东 济南 250001;
2. 济南市第三人民医院 检验科, 山东 济南 250001
关键词:胃癌 糖类抗原125 胃泌素17 血浆D-二聚体 M2型丙酮酸激酶 
分类号:R735.2
出版年·卷·期(页码):2019·47·第二期(179-182)
摘要:

目的:探讨血清糖类抗原125(CA125)、胃泌素17(G-17)及血浆D-二聚体(D-D)、M2型丙酮酸激酶(M2-PK)联合检测在胃癌早期诊断中的应用价值。方法:选取2016年9月至2017年9月间在我院治疗的胃癌患者70例作为观察组,并选取同期治疗的良性胃病患者45例作为疾病对照组,以及体检合格的志愿者45例作为健康对照组。对比三组血清CA125、G-17及血浆D-D、M2-PK水平及阳性检出率,以及上述各指标单独及联合检测在胃癌诊断中的灵敏度及特异度对。结果:观察组血清CA125、G-17及血浆D-D、M2-PK水平均显著高于两对照组(P<0.05);不同临床分期胃癌患者血清CA125、G-17及血浆D-D、M2-PK水平比较差异有统计学意义(P<0.05);观察组CA125、G-17、D-D及M2-PK检测的阳性率均显著高于两对照组(P<0.05);但健康对照组和疾病对照组的阳性率差别无统计学意义(P>0.05)。此外,血清CA125、G-17及血浆D-D、M2-PK四者联合检测的灵敏度相比于各指标单独检测均显著升高(P<0.05),而特异度相比于单独检测均有所降低,且相比于D-D、M2-PK差异有统计学意义(P<0.05)。结论:血清CA125、G-17及血浆D-D、M2-PK在胃癌的早期诊断中具有较高的应用价值,而四指标联合检测使诊断的灵敏度得以显著提高,在一定程度上避免了漏诊及误诊,对于胃癌的及早发现具有重要价值。

Objective:To explore the diagnostic value of the serum CA125, G-17, and plasma D-D, M2-PK in patients with gastric cancer.Methods:A total of 70 patients with gastric cancer who were treated in our Hospital from September 2016 to September 2017 were selected as observation group, 45 patients with benign gastric disorders treated in the same period as disease control group, and 45 normal volunteers as health control group. The level and positive rate of serum CA125, G-17, and plasma D-D, M2-PK were compared between the three groups, and the diagnostic efficency of CA125, G-17, D-D and M2-PK for gastric cancer was observed.Results:Serum CA125, G-17, and plasma D-D, M2-PK level were significantly higher in the observation group than thetwo control groups(P<0.05). The levels of CA125, G-17, D-D and M2-PK in different clinical stages were statistically significant(P<0.05). The positive rate of CA125, G-17, D-D and M2-PK were significantly higher in the observation group than that in the two control groups(P<0.05). The sensitivity of combined detection of serum CA125,G-17 and plasma D-D, XM2-PK was significantly higher than that of each alone(P<0.05); however, there was no significant difference in the positive rate between the healthy control group and the disease control group(P>0.05). The specificity of joint detection was lower than each detection alone; when compared with D-D, M2-PK, the difference were statistically significant(P<0.05).Conclusion:Serum CA125,G-17 and plasma D-DX M2-PK have high application value in early diagnosis of gastric cancer, and combined detection of four indexes can significantly improve the sensitivity of diagnosis and avoid missed diagnosis and misdiagnosis to a certain extent. It has important value for early detection of gastric cancer.

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