[1] VITEK L,HALUZIK M.The role of bile acids in metabolic regulation[J].J Endocrinol,2016,228(3):R85-96.
[2] WATANABE M,HOUTEN S M,MATAKI C,et al.Bile acids induce energy expenditure by promoting intracellular thyroid hormone activation[J].Nature,2006,439(7075):484-489.
[3] 钱荣立.关于糖尿病的新诊断标准与分型的意义[J].临床内科杂志,2000,17(3):133.
[4] MATTHEWS D R,HOSKER J P,RUDENSKI A S,et al.Homeostasis model assessment:insulinresistance and beta-cell function from fasting plasma glucose and insulin concentrations in man[J].Diabetologia,1985,28(7):412-419.
[5] 朱姿英,薛耀明.高甘油三酯血症和2型糖尿病[J].中国糖尿病杂志,2003,11(2):153-154.
[6] 陈望,刘尚全,刘心苑.2型糖尿病患者胰岛β细胞功能与血糖波动及不同血糖控制水平的相关性分析[J].现代医学,2018,46(2):204-208.
[7] LEFEBVRE P,CARIOU B,LIEN F,et al.Role of bile acids and bile acid receptors in metabolic regulation[J].Physiol Rev,2009,89(1):147-91.
[8] LI T,CHANDA D,ZHANG Y,et al.Glucose stimulates cholesterol 7alpha-hydroxylase gene transcription in human hepatocytes[J].J Lipid Res,2010,51(4):832-842.
[9] HAEUSLER R A,ASTIARRAGA B,CAMASTRA S,et al.Human insulin resistance is associated with increased plasma levels of 12alpha-hydroxylated bile acids[J].Diabetes,2013,62(12):4184-4191.
[10] CHARACH G,ARGOV O,GEIGER K,et al.Diminished bile acids excretion is a risk factor for coronary artery disease:20-year follow up and long-term outcome[J].Therap Adv Gastroenterol,2018,11:1756283x17743420.
[11] ANGELIN B,HERSHON K S,BRUNZELL J D.Bile acid metabolism in hereditary forms of hypertriglyceridemia:evidence for an increased synthesis rate in monogenic familial hypertriglyceridemia[J].Proc Natl Acad Sci U S A,1987,84(15):5434-5438.
[12] 徐辰祺,卜军,何奔.胆汁酸在心血管疾病中的作用[J].生理科学进展,2015,46(6):424-428.
[13] ZHANG Y,LEE F Y,BARRERA G,et al.Activation of the nuclear receptor FXR improves hyperglycemia and hyperlipidemia in diabetic mice[J].Proc Natl Acad Sci U S A,2006,103(4):1006-1011.
[14] POLS T W,NORIEGA L G,NOMURA M,et al.The bile acid membrane receptor TGR5 as an emerging target in metabolism and inflammation[J].J Hepatol,2011,54(6):1263-1272.
[15] PATHAK P,LIU H,BOEHME S,et al.Farnesoid X receptor induces Takeda G-protein receptor 5 cross-talk to regulate bile acid synthesis and hepatic metabolism[J].J Biol Chem,2017,292(26):11055-11069.
[16] OZCAN U,YILMAZ E,OZCAN L,et al.Chemical chaperones reduce ER stress and restore glucose homeostasis in a mouse model of type 2 diabetes[J].Science,2006,313(5790):1137-1140.
[17] PRAWITT J,ABDELKARIM M,STROEVE J H,et al.Farnesoid X receptor deficiency improves glucose homeostasis in mouse models of obesity[J].Diabetes,2011,60(7):1861-1871.
[18] ABDELKARIM M,CARON S,DUHEM C,et al.The farnesoid X receptor regulates adipocyte differentiation and function by promoting peroxisome proliferator-activated receptor-gamma and interfering with the Wnt/beta-catenin pathways[J].J Biol Chem,2010,285(47):36759-36767.
[19] 牛尚梅,韩卓笑,马慧娟.胆汁酸代谢与2型糖尿病[J].国际内分泌代谢杂志,2014,34(3):191-193.
[20] STEINER C,OTHMAN A,SAELY C H,et al.Bile acid metabolites in serum:intraindividual variation and associations with coronary heart disease,metabolic syndrome and diabetes mellitus[J].PLoS One,2011,6(11):e25006.
[21] SUN W,ZHANG D,WANG Z,et al.Insulin resistance is associated with total bile acid level in type 2 diabetic and nondiabetic population:a cross-sectional study[J].Medicine(Baltimore),2016,95(10):e2778.
[22] DAYER-BERENSON L,FINCKENOR M.Expanded colesevelam administration options with oral suspension formulation for patients with diabetes and hypercholesterolemia[J].Postgrad Med,2014,126(3):126-134.
[23] ELKELES R S.Colesevelam for type 2 diabetes mellitus:an abridged Cochrane review[J].Diabet Med,2014,31(7):880. |