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线粒体形态改变及pink1/parkin通路参与线粒体自噬的研究进展
作者:彭鑫  樊攀  吴小涛  王运涛 
单位:东南大学附属中大医院 脊柱外科中心, 江苏 南京 210009
关键词:线粒体自噬 融合 分裂 pink1/parkin通路 文献综述 
分类号:Q244
出版年·卷·期(页码):2019·47·第四期(483-487)
摘要:

线粒体是细胞内氧化呼吸链发生的主要场所,是为细胞提供ATP的"发电厂"。线粒体功能异常引起细胞能量供应障碍导致细胞衰亡。线粒体自噬是其自我修复的主要途径,线粒体损伤是引起自噬发生的主要原因之一。线粒体自噬与其形态变化、各种信号通路的介导等相互关联。大量研究证实线粒体自噬与帕金森病、糖尿病、心脏病、腰椎间盘退变等疾病有关。因此明确线粒体自噬相关分子机制并对其进行干预具有积极的临床意义。

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