Objective:To investigate the relationships of NF-κB in cardiovascular disease (CVD) patients with maintenance hemodialysis (MHD), and to evaluate the effect of NF-kappa B on the prognosis of MHD patients. Methods:A total of 160 patients with end-stage renal failure receiving MHD treatment in our hospital in January 2012 and more than 6 months were selected as the subjects, and the NF-κB level was detected by ELISA. All patients were followed up for 5 years to record the new non-fatal CVD and the cause and time of death. According to NF-κB, the patients were divided into four groups, group A (NF-κB<750.82 ng·mg-1), group B (750.82 ng·mg-1 ≤ NF-κB<1 142.42 ng·mg-1), group C (1 142.42 ng·mg-1 ≤ NF-κB<1 612.91 ng·mg-1 nucleoprotein), group D (NF-κB<1 612.9 ng·mg-1). Kaplan-meier survival curve was used to analyze the survival rate of all four groups due to death and CVD death. Results:There were significant differences in hs-CRP, NT-proBNP and diabetes prevalence among the four groups, and hs-CRP and NT-proBNPin group D were significantly higher than those in group A, group B and group C (P<0.05). There were significant differences in the incidence of coronary artery diseases, cerebrovascular accidents and peripheral artery occlusion in all kinds of non-fatal CVD, patients followed up for 5 years. The incidence of non-lethal CVD in group D was significantly higher than that in group A (P<0.008). There were significant differences in CVD mortality and all-cause mortality among the four groups (P<0.05). The survival rate of D group was lower than that of group A and B (P<0.05). Conclusion:The level of NF-κ B in peripheral blood mononuclear cells is closely related to CVD in patients with MHD. The increase of NF-κ B level can increase the incidence of CVD, and the prognosis of the patients is poor. |
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