目的：分析胃癌组织中长链非编码RNA（lncRNA）、乳腺癌易感基因（BRCA-1）的表达及其与紫杉醇药敏的相关性。方法：选取2015年1月至2017年1月间我院收治的68例采用紫杉醇化疗方案治疗的晚期胃癌患者作为研究对象，检测病灶组织中LncRNA HOX转录反义RNA（HOTAIR）、BRCA-1水平。结果：LncRNA HOTAIR和BRCA-1表达在患者不同性别、年龄和病理分型方面差异无统计学意义（P>0.05），疾病控制及进展的患者性别、年龄及病理分型差异无统计学意义（P>0.05），LncRNA HOTAIR和BRCA-1低表达的患者疾病控制例数较多（P<0.05），LncRNA HOTAIR及BRCA-1表达是影响患者治疗疗效的危险因素（P<0.05），LncRNA HOTAIR低表达患者生存率显著优于LncRNA HOTAIR高表达患者（P<0.05），BRCA-1低表达患者生存率显著优于BRCA-1高表达患者（P<0.05）。结论：晚期胃癌组织中LncRNA HOTAIR、BRCA-1高表达可能降低胃癌对紫杉醇的敏感性，并降低药效。

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