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晚期胃癌组织中LncRNA HOTAIR、BRCA-1的表达及药敏相关性
作者:张伟  张明雷  管天文  尹晓东 
单位:滨海县人民医院 肿瘤科, 江苏 盐城 224500
关键词:晚期胃癌 长链非编码RNA HOX转录反义RNA 乳腺癌易感基因 紫杉醇 药物敏感性 
分类号:R735.2
出版年·卷·期(页码):2019·38·第九期(1117-1121)
摘要:

目的:分析胃癌组织中长链非编码RNA(lncRNA)、乳腺癌易感基因(BRCA-1)的表达及其与紫杉醇药敏的相关性。方法:选取2015年1月至2017年1月间我院收治的68例采用紫杉醇化疗方案治疗的晚期胃癌患者作为研究对象,检测病灶组织中LncRNA HOX转录反义RNA(HOTAIR)、BRCA-1水平。结果:LncRNA HOTAIR和BRCA-1表达在患者不同性别、年龄和病理分型方面差异无统计学意义(P>0.05),疾病控制及进展的患者性别、年龄及病理分型差异无统计学意义(P>0.05),LncRNA HOTAIR和BRCA-1低表达的患者疾病控制例数较多(P<0.05),LncRNA HOTAIR及BRCA-1表达是影响患者治疗疗效的危险因素(P<0.05),LncRNA HOTAIR低表达患者生存率显著优于LncRNA HOTAIR高表达患者(P<0.05),BRCA-1低表达患者生存率显著优于BRCA-1高表达患者(P<0.05)。结论:晚期胃癌组织中LncRNA HOTAIR、BRCA-1高表达可能降低胃癌对紫杉醇的敏感性,并降低药效。

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