支气管哮喘（以下简称"哮喘"）是一种呼吸道疾病，国内外普遍认为其主要病理生理机制是呼吸道炎症和气道重塑，气道重塑由不同的炎症途径介导，靶向抑制这些炎症途径在哮喘治疗方面效果显著。血管内皮生长因子（VEGF）、细胞间黏附分子-1（ICAM-1）及一氧化氮（NO）等细胞因子在哮喘呼吸道炎症和重塑中起着十分重要的作用，本文中作者从上述细胞因子的分子特点、结构及在哮喘中的作用等方面作一综述。

[1] Global Initiative for Asthma (GINA).Global strategy for asthma management and prevention(2015 updated)[S].2015.
[2] THOMPSON P J,SALVI S,LIN J,et al.Insights,attitudes and perceptions about asthma and its treatment:findings from a multinational survey of patients from 8 Asia-Pacific countries and Hong Kong[J].Respirology,2013,18(6):957-967.
[3] 孙妍,王金荣,韩秀珍,等.布地奈德对慢性支气管哮喘小鼠肺组织HIF-1α和VEGF表达及气道重塑的影响[J].中国当代儿科杂志,2012,14(8):622-627.
[4] 中华医学会呼吸病学分会哮喘学组.支气管哮喘防治指南(支气管哮喘的定义、诊断、治疗和管理方案)[J].中华结核和呼吸杂志,2016,39(9):675-697.
[5] FAHY J V,DICKEY B F.Airway mucus function and dysfunction[J].N Engl J Med,2010,363:2233-2247.
[6] CHOL I S,BYEON J H,YOU Y,et al.Increased serum interleukin-5 and vasculsF endothelial growth factor in children with acute mycoplasma Pneumonia and wheeze[J].Pediatr Pulmonol,2009,44(5):423-428.
[7] MURA M,SANTOS C C,STEWART D,et al.Vascular endothelial growth factor and related molecules in acute lung injury[J].J Appl Phycol,2004,97(5):1605-1617.
[8] 王志虹,林江涛,农英,等.血管内皮生长因子受体抑制剂对小鼠支气管哮喘模型气道炎症和气道重塑的影响[J].中华结核和呼吸杂志,2005,28(11):23-27.
[9] HWADA A,YOSHIOKA Y,IWABUCHI K,et al.VEGF regulates the proliferation of acid-exposed alveolar lining epithelial cells[J].Thorax,2003,58(4):328-332.
[10] 戴峰,张秀明,陈骏,等.肝细胞肝癌TAE前后血清HIF-1α、VEGF表达与疗效的相关性研究[J].东南大学学报(医学版),2016,35(4):537-540.
[11] 高春梅.VEGF及其受体在哮喘及其发病机制中的研究进展[J].河北医药,2009,32(27):2303-2305.
[12] KNOX A J,CORBETT L,STOCKS J,et al.Human airway smooth muscle cells secrete vascular endothelial growth factor:up-regulation by bradykinin via a protein kinase C and prostanoid-dependent mechanism[J].FASEB J,2001,15(13):2480-2488.
[13] FELSTRTZER C,KANELDER N C,STURN D H,et al.ExPression and function of the vascular endothelial growth factor receptor FIT-1 in human eosinophils[J].Am J Respir Cell Mol Biol,2004,30(5):729-735.
[14] STE P T,ALEXAANDRA N,ALAN C,et al.An anti-human ICAM-1 antibody inhibits rhinovirus-induced exacerbations of lung inflammation[J].PLoS Pathog,2013,9(8):e1003520.
[15] 张朝顺,冯起校,覃善君,等.雷公藤甲素对支气管哮喘小鼠STAT-1及ICAM-1表达的影响[J].国际呼吸杂志,2014,34(7):961-966.
[16] NIE Z,FRYER A D,JACOBY D B.β2-agonists inhibit TNF-α-induced ICAM-1 expression in human airway parasympathetic neurons[J].PLoS One,2012,7(9):e44780.
[17] KONRAD P,TRAVIS W Y,SUSAN S,et al.Cross-talk between ICAM-1 and granulocyte-macrophage colony-stimulating factor receptor signaling modulates eosinophil survival andactivation[J].J Immunol,2008,180(6):4182-4190.
[18] 刘晨,刘明娜,张华,等.哮喘患儿血清可溶性细胞间黏附分子-1水平的检测研究[J].实用儿科临床杂志,2005,20(4):319-320.
[19] 黄铁群,林耀广,郭子健,等.内皮素和一氧化氮的失平衡在哮喘发病中的作用[J].中国病理生理杂志,2001,17(5):435-437.
[20] 李绍波,赖小英,金小红.内源性H2S/CSE和NO/iNOS体系与哮喘的关系研究[J].预防医学,2018,30(3):286-288.
[21] 黄铁群,林耀广,朱元珏,等.内源性一氧化氮在哮喘大鼠气道高反应性中的作用[J].中华结核和呼吸杂志,2015,22(12):717-719.