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细胞程序性死亡诱导的坏死性炎症与糖尿病肾病的研究概述
作者:唐敏  颜晓勇 
单位:遵义医科大学附属医院 肾内科, 贵州 遵义 563000
关键词:细胞程序性死亡 坏死性炎症 糖尿病肾病 综述 
分类号:R587.2;R329.25
出版年·卷·期(页码):2019·47·第十二期(1561-1565)
摘要:

细胞程序性死亡(PCD)在多种疾病进展和体内平衡的控制中起关键作用,主要包括坏死性凋亡、细胞焦亡和中性粒细胞胞外陷阱等。坏死性炎症是凋亡细胞坏死引发的炎症反应,释放的炎性细胞因子和损伤相关分子模式使环境倾向于促炎症状态。研究表明,高血糖引发的肾损伤可激活多种促炎信号启动PCD途径,本综述简要阐述PCD诱导的坏死性炎症与糖尿病肾病之间的关联。

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