Objective: To analyze the distribution and prognosis of tumor infiltrating inflammatory cells in nasopharyngeal carcinoma.Methods: From October 2009 to October 2013 paraffin specimens of 158 patients with nasopharyngeal carcinoma in our hospital were analyzed by immunohistochemistry to detect FOXP3, CD8+, CD4+, NE+, CD56+, CD20+, CD83+, CD1a+ and tryptase+ cell distribution, content and prognosis condition.Results: According to the density of inflammatory cells into the high density group and low density group, CD3+, CD20+, CD83+ and tryptase+ infiltration density was correlated with different pathological classification, FOXP3, NE+ and tryptase+ infiltration density was correlated with different N grade (P<0.05), FOXP3, NE+ infiltration density was correlated with different clinical stages (P<0.05). The survival rate of CD8+, tryptase, NE+ and FOXP3+ was higher than that of high density group, and the survival rate of CD1a+ and CD56+ was higher than that of low density, the difference was statistically significant (P<0.05). Conclusion: The content of tumor infiltrating mast cells, cytotoxic T cells and regulatory T cells is closely related to the poor prognosis of nasopharyngeal carcinoma patients. CD56+ NK cells are associated with the prognosis of CD1a+ immature dendritic cells and patients. |
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