Objective: To study the relation between heat shock protein 70 (HSP70), connexin 43 (CX43) and stress ulceration (SU) induced by acute myocardial infarction (AMI). Method: 120 patients with AMI were recruited from Jun 2017 to Dec 2017, and blood samples were obtained in the first 24 hours after patients arrived hospital. They were divided into four groups (KillipⅠ, KillipⅡ, KillipⅢ, KillipⅣ) according to Killip classification. HSP70 and CX43 were detected by ELISA, and hemoglobin reduction levels were analyzed in each groups. Also, the patients were divided into two groups (AMI group and AMI+SU group) according whether occured in SU. The HSP70 and CX43 levels and Hb reduction levels were analyzed. The relation between HSP70, CX43 and Hb reduction levels were analyzed. Result: In the four groups, the levels of HSP70 andCX43 were (Ⅰ:63±4.182 pg·mL-1, 107±3.63 pg·mL-1; Ⅱ:69±3.19 pg·mL-1, 111±5.63 pg·mL-1; Ⅲ:65±2.61 pg·mL-1, 105±4.09 pg·mL-1; Ⅳ:67±4.09 pg·mL-1, 1115±5.63 pg·mL-1), there were no statistically significant difference between the groups (P>0.05). Besides, the Hb reduction levels were (5.4±0.9 g·L-1, 7.6±0.8 g·L-1, 6.4±0.5 g·L-1, 5.9±0.4 g·L-1), there were no statistically significant difference between the groups (P>0.05). In the two groups, compared with the AMI group, the levels of HSP70 (76±2.14 pg·mL-1) and CX43 (145±4.63 pg·mL-1) in AMI+SU group were significantly increased (P<0.05); the hemoglobin reduction levels in AMI+SU group (17±2.1 g·L-1) were significantly higher than AMI group (7±1.1 g·L-1) (P<0.05). Besides, HSP70 and CX43 have a negative correlation with SU induced by AMI (P<0.05).Conclusion: HSP70 and CX43 have nocorrelation with AMI severity, but have correlated with AMI concurrent SU and could predict SU occurrence. |
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