Objective: To investigate the gender differences in the characteristics, clinical manifestations, and in-hospital outcomes of patients with ST-segment elevation myocardial infarction.Methods: Patients with STEMI admitted to 5 hospitals were selected in the years of 2001, 2006 and 2011, the differences of hospitalization rates, clinical profiles and quality of care were studied. Results: Among 491 patients, the proportion of female patients (30%) was significantly lower than that of men. The average age of male and female patients increased from 60.5 and 69 years in 2001 to 64 and 73 years in 2011(P=0.016, 0.458). After age correction, the proportion of female patients with hypertension (47.6% vs 38.7%, P=0.057 3), diabetes (19.6% vs 10.8%, P=0.007 4) and coronary heart disease (31.5% vs 21.4%, P=0.013 2) was higher than that of male patients; smoking was one of the main pathogenic factors in male patients (P<0.001); female patients had a lower rate of timely visit; among patients without contraindication, female patients received more drugs such as aspirin, while male patients received reperfusion treatment (23.8%, P=0.025%) and clopidogrel (4.1.4%, P=0.008). The mortality rate of hospital female patients was much higher than that of male patients (13.1% vs 5%, P=0.001 4). In different years, male patients were more than female patients. In terms of the acceptance of effective therapy, reperfusion therapy and PCI treatment, more male patients than female patients accepted, and the hospital mortality rate of female patients was maintained at a higher level.Conclusion: Acute STEMI patients have certain gender differences, women have more complications, later admission, lower cognition and acceptance of further treatment, and higher mortality rates in the hospital.
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