Objective: To investigate the effect of enteral nutrition, nerve function and intestinal mucosal barrier function in patients with severe hypertensive intracerebral hemorrhage(HICH). Methods: From March 2017 to February 2018, 98 patients with severe HICH were divided into two groups by Kendall coefficient blind method. In the naso-jejunumgroup (n=49), early naso-jejunal nutrition was carried out at different time of HICH in 16 cases (24 hours after operation), 16 cases (25-48 h after operation) and 17 cases (49-72 h after operation). In the nasogastric tube group(n=49), 16 cases (24 hours after operation), 16 cases (25-48 h) at T2 stage (postoperative 49-72 h) and 17 cases (49-72 h after operation) were given nasogastric tube enteral nutrition respectively. The Hb,Glu,BUN,Alb, neurological function index (S100B) and intestinal mucosal barrier function (DAO,D- lactic acid) were compared in each group to evaluate the improvement of GCS score in patients with HICH at day 14 and day 28 after operation, and the complications of both groups were recorded.Results: After 14 days of nasal feeding EEN, the Alb,S100B,NSF,GFAP,MBP,GCS score and DAO,D- lactic acid in the naso-jejunumgroup and the nasogastric tube group were significantly improved (P<0.05). In the naso-jejunum group, the DAO,D- lactic acid was significantly improved in the patients with EEN at 14 days after operation (P<0.05), and the EEN intervention in the naso-jejunum group at T2 stage was the best (P<0.05), and the improvement of DAO,D- lactic acid was better than that in the nasogastric tube group (P<0.05). Postoperative complications in the naso-jejunal group were significantly lower than those in the nasogastric tube group (P<0.05), and the incidence of complications in the naso-jejunum group was the lowest when EEN was used in T2 period.Conclusion: The establishment of naso-jejunal feeding via naso-jejunal feeding in 25-48 h after severe HICH can promote the recovery of intestinal function, metabolic function, reduce complications and improve nerve function.
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