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人工周期和自然周期冻融胚胎移植后围产期并发症及新生儿情况比较
作者:孙寒香  于长清  高玉平 
单位:上海交通大学医学院附属新华医院 妇产科, 上海 200082
关键词:人工周期 自然周期 围产期并发症 新生儿 
分类号:R714.7
出版年·卷·期(页码):2020·48·第十一期(1367-1371)
摘要:

目的:比较人工周期(artificial cycle,AC)和自然周期(natural cycle,NC)冻融胚胎移植后孕产妇围产期并发症及新生儿情况。方法:采用回顾性队列研究设计,分析2018年1月至2019年5月间进行冻融胚胎移植并最终活产分娩的孕妇及新生儿的临床资料。本研究共183个周期,其中AC组143例,NC组40例。比较AC组和NC组孕妇的围产期并发症和新生儿缺陷等相关指标。结果:AC组和NC组孕妇的年龄差异无统计学意义(P>0.05);AC组单胎和多胎的母亲患妊娠期高血压疾病的风险与NC组相比差异无统计学意义(P>0.05)。AC组孕妇分娩孕周、剖宫产率、妊娠期糖尿病、多胎、宫颈机能不全、胎儿宫内窘迫、孕妇B族链球菌(GBS)感染、肝功能损害、甲状腺功能异常、胎膜早破、胎盘早剥、胎盘前置、胎盘粘连、羊水过多或羊水过少、产妇入ICU、产后出血等发生率与NC组比较,差异均无统计学意义(P>0.05);AC组与NC组比较,新生儿并发症(包括新生儿窒息、呼吸窘迫综合征、高胆红素血症、低体重儿等)发生率差异无统计学意义(P>0.05),新生儿入ICU发生率差异有统计学意义(P<0.05);两组新生儿缺陷(包括心脏畸形、消化道畸形、泌尿系统畸形、膈疝等)发生率比较,差异均无统计学意义(P>0.05)。结论:与NC组相比,AC组孕妇围产期并发症及新生儿情况无明显差异,但新生儿入ICU发生率高。

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