Objective: To identify the incidence and risk factors of perianal diseases on pregnant and puerperal womenin Nanjing Jiangbei new area. Methods: 500 consecutive pregnant women invited to enter the study from March 2019 to February 2020. 460 women agreed to participate in the study during their pregnancy until puerperium were included. The women were divided into two groups: women in one group had developed the perianal disease, the other group had not. All significant univariate risk factors were included in a multiple Logistic regression model to identify independent risk factors. Calculations were performed using the statistical software package SPSS, version 25. Results: In all, 271(58.91%) women developed perianal disease, 44(16.24%) in the first trimester, 122(45.02%) during the last trimester, 100(36.9 %) after delivery and 5(1.09%) until puerperium; 187(69%) women were diagnosed with haemorrhoids, 29(10.7%) with anal fissure, 26(9.6%) with anal eczema and secretion increase, 24(8.9%) with rectal distension and tingling discomfort, 3(1.1%) with anal fistula, 2(0.7%) with anal papilloma. Multivariate analysis identified constipation, personal history of perianal diseases, late birth after 39 weeks of pregnancy, birthweight of newborn>3.8 kg, and straining during delivery for more than 20 minutes as significant predictors of benign perianal disease during pregnancy and perinatal period(P<0.05). Conclusion: Perianal benign diseases are common during the last trimester of pregnancy and childbirth, with constipation, personal history of perianal diseases, birthweight of newborn>3.8 kg, straining during delivery for more than 20 minutes being independently associated risk factors.
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