脉络宁注射液联合丁苯酞软胶囊对急性脑梗死患者血液流变学及炎症因子水平的影响-现代医学

脉络宁注射液联合丁苯酞软胶囊对急性脑梗死患者血液流变学及炎症因子水平的影响

单位：1. 南京大学医学院附属鼓楼医院药学部, 江苏南京 210008;
2. 南京大学医学院附属鼓楼医院老年科, 江苏南京 210008

分类号：R973

出版年·卷·期（页码）：2020·48·第十二期（1515-1518）

摘要：

目的： 探究脉络宁注射液联合丁苯酞软胶囊对急性脑梗死患者的血液流变学以及炎症因子水平的影响。方法： 选取2017年6月至2019年6月本院收治的120例急性脑梗死患者为研究对象，按照治疗方法不同分为对照组（脉络宁注射液）和治疗组（脉络宁注射液联合丁苯酞软胶囊），每组60例。患者均接受14 d治疗。比较两组的临床疗效、国立卫生研究院卒中量表（NIHSS）评分、改良Rankin量表（mRS）评分、血液流变学指标、炎症因子水平的差异。结果： 治疗组总有效率高于对照组，差异有统计学意义（P<0.05）。治疗组NIHSS评分、mRS评分均低于对照组，差异均有统计学意义（均P<0.05）。治疗组全血黏度（WBV）高切、WBV低切、血浆黏度（PV）、红细胞沉降率（ESR）、肿瘤坏死因子-α（TNF-α）、白细胞介素6（IL-6）水平均低于对照组，差异均有统计学意义（均P<0.05）。结论： 脉络宁注射液联合丁苯酞软胶囊可显著改善急性脑梗死患者血液流变学指标及TNF-α、IL-6水平，保护患者神经功能。

Objective: To explore the effect of Mailuoning injection combined with Butylphthalide soft capsule in treatment of acute cerebral infarction.Methods: Patients with acute cerebral infarction from June 2017 to June 2019 were divided into two group according to treatment method. Control group:patients were given Mailuoning injection. Treatment group:patients were given Butylphthalide soft capsule 2 capsules combined withcontrol group treatment. All patients were treated for 14 days. Then clinical efficacies, National Institute of Health stroke scale(NIHSS) scores, modified Rankin scale(mRS) scores, blood rheology indexes, and inflammatory factors were evaluated and compared.Results: The clinical efficacy rate of treatment group was higher than that of control group(P<0.05). NIHSS scores and mRS scores in the treatment group were significantly lower than those in the control group(P<0.05). The levels of whole blood viscosity(WBV), plasma viscosity(PV), erythrocyte sedimentation rate(ESR), tumor necrosis factor-α(TNF-α) and interleukin-6(IL-6) in the treatment group were significantly lower than those in the control group(all P<0.05).Conclusion: Mailuoning injection combined with Butylphthalide soft capsule can ameliorate blood rheology indexes and levels of TNF-α and IL-6 inacute cerebral infarction patients, and then recover patients nervous function.

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