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阿帕替尼在临床应用中不良反应的研究进展
作者:张倩1 2  杜家虞1 2  唐洁1 2  严浩吉3  马晓洁1 3 
单位:1. 川北医学院附属医院 肿瘤科, 四川 南充 637000;
2. 川北医学院 临床医学系, 四川 南充 637000;
3. 川北医学院 医学影像学院, 四川 南充 637000
关键词:阿帕替尼 抗血管生成药 不良反应 综述 
分类号:R979.1
出版年·卷·期(页码):2021·49·第一期(109-113)
摘要:

阿帕替尼是我国自主研制的用于晚期胃癌或胃-食管结合部腺癌三线或三线以上治疗的小分子靶向药,目前已在非小细胞肺癌、乳腺癌、肝癌、甲状腺癌等多种实体肿瘤中开展临床试验及广泛应用,虽然有可观的疗效及生存获益,但也合并了多种不良反应,影响患者的生活质量,严重者导致用药剂量减少或停药,减弱药物疗效,限制了药物的临床应用。本文作者总结了阿帕替尼在临床应用中常见的不良反应及其产生的机制,为预防和治疗多种不良反应提供重要帮助。

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