Objective:To investigate the influence of laparoscopic vagus nerve-preserving distal gastrectomy (VPG) on the postoperative quality of life (QOL) in patients with early stage distal gastric cancer.Methods: 142 patients with early-stage distal gastric cancer weredivided into VPG group (n=73) and conventional distal gastrectomy (CG) group (n=69). All the patients of the two groups underwent laparoscopic VPG and CG respectively. The perioperative indicators, survival and recurrence within 3 years after surgery were compared between the two groups. The Quality of Life Questionnare-Core 30(QLQ-C30) and Quality of Life Questionnare-Stomach Cancer 22(QLQ-STO22) were used to evaluate the QOL. Results: The anus exhaust time was significantly shorter in the VPG group than that in the CG group (P<0.05), but there was no significant difference in the number of lymph node dissection, operation time and intraoperative blood loss between the two groups (P>0.05). 3 months after surgery, fatigue, nausea and vomiting, appetite loss, constipation, diarrhea scores of QLQ-C30 and eating restriction, reflux, thirst, body image scores of QLQ-STO22 scale in the VPG group were significantly lower than those in the CG group (P<0.05); 12 months after surgery, appetite loss, diarrhea and body image scores in the VPG group were significantly lower than those in the CG group (P<0.05). The 1-year and 3-year survival rates, cumulative recurrence rate were 100%, 95.89% and 8.22% in the VPG group respectively, compared with 100.00%, 97.10% and 5.80% in the CG group, the difference was not statistically significant (P>0.05).Conclusion:Laparoscopic VPG is safe and effective in the treatment of early-stage distal gastric cancer, which can reduce the diarrhea, appetite loss, body shape change and improve the postoperative quality of life at 1 year after surgery.
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