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晚期卵巢上皮性肿瘤治疗型疫苗研究进展
作者:陈羽翕  谭小军 
单位:南华大学教学医院湘潭市中心医院 生殖与遗传中心, 湖南 湘潭 411100
关键词:晚期卵巢上皮性肿瘤 肿瘤疫苗 免疫治疗 文献综述 
分类号:R737.31
出版年·卷·期(页码):2021·49·第五期(592-597)
摘要:

肿瘤治疗型疫苗即多肽/蛋白疫苗、核酸疫苗、活载体疫苗、细胞疫苗、个性化疫苗,对晚期卵巢上皮性肿瘤的治疗,较之目前临床上传统肿瘤细胞减灭术加以铂类药物为主的化疗,不仅毒副作用小,且疗效喜人。作者就近年来有关晚期卵巢上皮性肿瘤治疗型疫苗的研究进展作一综述。

参考文献:

[1] MATULONIS U A,SOOD A K,FALLOWFIELD L,et al.Ovarian cancer[J].Nat Rev Dis Primers,2016,2:16061.
[2] MOORE K N,OZA A M,COLOMBO N,et al.Phase Ⅲ,randomized trial of mirvetuximab soravtansine versus chemotherapy in patients with platinum-resistant ovarian cancer:primary analysis of FORWARD Ⅰ[J].Ann Oncol,2021,32(6):757-765.
[3] 赵灵.化疗对上皮性卵巢癌免疫逃逸相关分子CD47和PD-L1表达的影响[D].北京:北京协和医学院,2018.
[4] SHAO F,LIU J,DUAN Y,et al.Efficacy and safety of PARP inhibitors as the maintenance therapy in ovarian cancer:a meta-analysis of nine randomized controlled trials[J].Biosci Rep,2020,40(3):BSR20192226.
[5] GOODELL V,SALAZAR L G,URBAN N,et al.Antibody immunity to the p53 oncogenic protein is a prognostic indicator in ovarian cancer[J].J Clin Oncol,2006,24:762-768.
[6] SATO E,OLSON S H,AHN J,et al.Intraepithelial CD8+ tumor-infiltrating lymphocytes and a high CD8+/regulatory T cell ratio are associated with favorable prognosis in ovarian cancer[J].Proc Natl Acad Sci U S A,2005,102(51):18538-18543.
[7] ZSIROS E,TANYI J,BALINT K,et al.Immunotherapy for ovarian cancer:recent advances and perspectives[J].Curr Opin Oncol,2014,26(5):492-500.
[8] KAWANO K,TSUDA N,MATSUEDA S,et al.Feasibility study of personalized peptide vaccination for recurrent ovarian cancer patients[J].Immunopharmacol Immunotoxicol,2014,36:224-236.
[9] SPINOSA J P,KANDUC D.Ovarian cancer:designing effective vaccines and specific diagnostic tools[J].Immunotherapy,2014,6:35-41.
[10] ALESSANDRA B,MARCO F,ALEXIA B,et al.A robust immune system conditions the responseto abagovomab(anti-idiotypic monoclonal antibody mimicking the ca125 protein) vaccination in ovarian cancer patients[J].Immunol Lett,2017,191:35-39.
[11] CHENG H,YE X,CHANG X,et al.Construction,expression,and function of 6B11ScFv-mIL-12,a fusion protein that attacks human ovarian carcinoma[J].Med Oncol,2015,32(4):130.
[12] SENOVILLA L,VACCHELLI E,GARCIA P,et al.Trial watch:DNA vaccines for cancer therapy[J].Oncoimmunology,2013,2(4):e23803.
[13] DOWD K A,KO S Y,MORABITO K M,et al.Rapid development of a DNA vaccine for Zika virus[J].Science,2016,354:237-240.
[14] BARRETT ALAN D T.Zika vaccine candidates progress through nonclinical development and enter clinical trials[J].NPJ Vaccines,2016,1:16023.
[15] PERALES P A,WOJTAK K,DUPERRET E K,et al.Engineered DNA vaccination against follicle-stimulating hormone receptor delays ovarian cance progression in animal models[J].Mol Ther,2019,27:314-25.
[16] GABAI-VLADIMIR L,SHIFRIN-VICTOR I.Feasibility analysis of p62(SQSTM1)-encoding DNA vaccine as a novel cancer immunotherapy[J].Int Rev Immunol,2014,33:375-82.
[17] DMITRY M,PONOMARENKO I D K,YULIA A,et al.Safety and efficacy of p62 DNA vaccine ELENAGEN in a first-in human trial in patients with advanced solid tumors[J].Oncotarget,2017,8(32):53730-53739.
[18] LIZOTTE P H,WEN A M,SHEEN M R,et al.In situ vaccination with cowpea mosaic virus nanoparticles suppresses metastatic cancer[J].Nat Nanotechnol,2016,11(3):295-303.
[19] CZAPAR A E,TIU B D B,VELIZ F A,et al.Slow-release formulation of cowpea mosaic virus for in situ vaccine delivery to treat ovarian cancer[J].Adv Sci(Weinh),2018,5:1700991.
[20] WANG C,STEINMETZ-NICOLE F.CD47 blockade and cowpea mosaic virus nanoparticle in situ vaccination triggers phagocytosis and tumor killing[J].Adv Healthc Mater,2019,8:e1801288.
[21] TSCHOFEN M,KNOPP D,HOOD E,et al.Plant molecular farming:much more than medicines[J].Annu Rev Anal Chem(Palo Alto Calif),2016,9(1):271-294.
[22] KANERVA A,NOKISALMI P,DIACONU I,et al.Antiviral and antitumor T-cell immunity in patients treated with GM-CSF-coding oncolytic adenovirus[J].Clin Cancer Res,2013,19:2734-2744.
[23] WOLLER N,GVRLEVIK E,FLEISCHMANN-MUNDT B,et al.Viral infection of tumors overcomes resistance to PD-1-immunotherapy by broadening neoantigenome-directed T-cell responses[J].Mol Ther,2015,23:1630-1640.
[24] SANTOS J M,HEINIÖ C,CERVERA C V,et al.Oncolytic adenovirus shapes the ovarian tumor microenvironment for potent tumor-infiltrating lymphocyte tumor reactivity[J].J Immunother Cancer,2020,8:e000188.
[25] WU D,WANG J,CAI Y L,et al.Effect of targeted ovarian cancer immunotherapy using ovarian cancer stem cell vaccine[J].J Ovarian Res,2015,8:68.
[26] HELLSTRÖM I,GOODMAN G,PULLMAN J,et al.Overexpression of HER-2 in ovarian carcinomas[J].Cancer Res,2001,61(6):2420-2423.
[27] BORELLA F,GHISONI E,GIANNONE G,et al.Immune checkpoint inhibitors in epithelial ovarian cancer:an overview on efficacy and future perspectives[J].Diagnostics(Basel),2020,10(3):146-163.
[28] CHU C S,Boyer J,Schullery D S,et al.Phase Ⅰ/Ⅱ randomized trial of dendritic cell vaccination with or without cyclophosphamide for consolidation therapy of advanced ovarian cancer in first or second remission[J]. Cancer Immunology Immunotherapy, 2012, 61(5):629-641.
[29] SCARANTI M,COJOCARU E,BANERJEE S,et al.Exploiting the folate receptor α in oncology[J].Nat Rev Clin Oncol,2020,17(6):349-359.
[30] BRAND C,SADIQUE A,HOUGHTON J L,et al.Leveraging PET to image folate receptor alpha therapy of an antibody-drug conjugate[J].EJNMMI Res,2018,8(1):87-97.
[31] HERNANDO J J,PARK T W,FISCHER H P,et al.Vaccination with dendritic cells transfected with mRNA-encoded folate-receptor-α for relapsed metastatic ovarian cancer[J].Lancet Oncol,2007,8:451-454.
[32] CAO Y,BLOHM D,GHADIMI B M,et al.Mucins(MUC1 and MUC3) of gastrointestinal and breast epithelia reveal different and heterogeneous tumor-associated aberrations in glycosylation[J].J Histochem Cytochem,1997,45:1547-1557.
[33] GRAY H J,BENIGNO B,BEREK J,et al.Progression-free and overall survival in ovarian cancer patients treated with CVac,a mucin 1 dendritic cell therapy in a randomized phase 2 trial[J].J Immunother Cancer,2016,4:34.
[34] CHENG W F,HUANG C Y,CHANG M C,et al.High mesothelin correlates with chemoresistance and poor survival in epithelial ovarian carcinoma[J].Br J Cancer,2009,100:1144-1153.
[35] 梁振,董郊,李凤杰,等.FOLR1与MSLN蛋白在上皮性卵巢癌组织中的表达及临床意义[J].第三军医大学学报,2020,42(2):133-140.
[36] 王东晖.间皮素在卵巢上皮癌中的诊断价值及负载间皮素的DC疫苗抗卵巢癌细胞效应的研究[D].石家庄:河北医科大学,2015.
[37] FACCIPONTE J G,WANG X Y,MACDONALD I J,et al.Heat shock proteins HSP70 and GP96:structural insights[J].Cancer Immunol Immun,2006,55(3):339-346.
[38] ZHENG H G,LIU L L,ZHANG H,et al.Correction:Dendritic cells pulsed with placental gp96 promote tumor-reactive immune responses[J].PLoS One,2019,14:e0218362.
[39] 杨淑莉,金月梅,付莉,等.负载gp96多肽复合物的树突状细胞抗耐药卵巢癌细胞株作用的实验研究[J].中国妇幼保健,2008,33:4759-4762.
[40] MCGRANAHAN N,FURNESS A J S,ROSENTHAL R,et al.Clonal neoantigens elicit T cell immunoreactivity and sensitivity to immune checkpoint blockade[J].Science,2016,351:1463-1469.
[41] MAOZ A,RENNERT G,GRUBER S B.T-cell transfer therapy targeting mutant KRAS[J].N Engl J Med,2017,376:e11.
[42] VAN A E M,MIAO D,SCHILLING B,et al.Genomic correlates of response to CTLA-4 blockade in metastatic melanoma[J].Science,2015,350:207-211.
[43] YADAV M,JHUNJHUNWALA S,PHUNG Q T,et al.Predicting immunogenic tumour mutations by combining mass spectrometry and exome sequencing[J].Nature,2014,515:572-576.
[44] GUBIN M M,ZHANG X L,SCHUSTER H,et al.Checkpoint blockade cancer immunotherapy targets tumour-specific mutant antigens[J].Nature,2014,515:577-581.
[45] OPHIR E,BOBISSE S,COUKOS G,et al.Personalized approaches to active immunotherapy in cancer[J].Biochem Biophys Acta,2016,1865(1):72-82.
[46] SARIVALASIS A,BOUDOUSQUIE C,BALINT K,et al.A Phase Ⅰ/Ⅱ trial comparing autologous dendritic cell vaccine pulsed either with personalized peptides(PEP-DC) or with tumor lysate(OC-DC) in patients with advanced high-grade ovarian serous carcinoma[J]. Transl Med,2019,17:391-401.
[47] TANYI J L,BOBISSE S,OPHIR E,et al.Personalized cancer vaccine effectively mobilizes antitumor T cell immunity in ovarian cancer[J].Sci Transl Med,2018,10(436):eaao5931.
[48] CHIANG C L,KANDALAFT L E,TANYI J,et al.A dendritic cell vaccine pulsed with autologous hypochlorous acid-oxidized ovarian cancer lysate primes effective broad antitumor immunity:from bench to bedside[J].Clin Cancer Res,2013,19(17):4801-4815.
[49] MARTIN S D,BROWN S D,WICK D A,et al.Low mutation burden in ovarian cancer may limit the utility of neoantigen-targeted vaccines[J].PLoS ONE,2016,11(5):e0155189.
[50] ODUNSI K,QIAN F,MATSUZAKI J,et al.Vaccination with an NY-ESO-1 peptide of HLA class Ⅰ/Ⅱ specifcities induces integrated humoral and T cell responses in ovarian cancer[J].Proc Natl Acad Sci U S A,2007,104(31):12837-12842.
[51] OTT P A,HU Z,KESKIN D B,et al.An immunogenic personal neoantigen vaccine for patients with melanoma[J].Nature,2017,547:217-221.
[52] OTT P A,GOVINDAN R,NAING A,et al.A personal neoantigen vaccine,NEO-PV-01,with anti-PD1 induces broadde novo anti-tumor immunity in patients with metastatic melanoma,NSCLC and bladder cancer[J].Ann Oncol,2018,29:400-441.
[53] SAHIN U,DERHOVANESSIAN E,MILLER M,et al.Personalized RNA mutanome vaccines mobilize poly-specific therapeutic immunity against cancer[J].Nature,2017,547(7662):222-226.

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