目的：探讨白藜芦醇对人肺腺癌细胞（A549细胞）迁移及侵袭的作用及其作用机制。方法：实验分为空白对照组、白藜芦醇干预组（分别以30 μmol·L^-1、50 μmol·L^-1、100 μmol·L^-1的白藜芦醇干预A549细胞24 h或48 h）。划痕试验检测各组A549细胞的迁移能力，transwell小室试验检测各组A549细胞的侵袭能力。qRT-PCR检测各组磷酸鞘氨醇（S1P）及磷酸鞘氨醇受体3（SIPR3）的mRNA表达，Western blotting检测各组S1P及SIPR3的蛋白表达。结果：划痕实验证实白藜芦醇明显抑制A549细胞的迁移能力。Transwell小室实验证实白藜芦醇明显抑制A549细胞的侵袭能力。qRT-PCR检测发现白藜芦醇使S1P及SIPR3的mRNA表达水平下调。Western blotting检测发现白藜芦醇使S1P及SIPR3的蛋白表达水平下调。结论：白藜芦醇通过调控S1P/SIPR3通路从而抑制A549细胞的迁移及侵袭。

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