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瞬时受体电位香草素4与恶性肿瘤发生发展关系的研究进展
作者:廖贤琴1  曾宪海1 2  张鹏2  邱书奇1 2 
单位:1. 遵义医科大学珠海校区, 广东 珠海 519041;
2. 深圳市龙岗区耳鼻咽喉医院/深圳市耳鼻咽喉研究所, 广东 深圳 518172
关键词:瞬时电位受体香草素4 恶性肿瘤 诊断标记物 治疗靶点 文献综述 
分类号:R730.2
出版年·卷·期(页码):2021·49·第六期(691-695)
摘要:

瞬时受体电位香草素4(TRPV4)是瞬时受体电位(TRP)通道家族的成员之一。TRPV4可以通过各种物理和化学刺激激活,包括热、机械力、渗透压和佛波酯衍生物等。近年来,TRPV4在细胞增殖、分化、凋亡和迁移中的作用得到广泛研究。TRPV4的异常表达也与多种恶性肿瘤的发生和发展密切相关,因此它可能成为癌症诊断和治疗的靶标。本文综述TRPV4在恶性肿瘤发生发展中的研究进展,并对其作为治疗靶点和诊断标志物的潜力进行展望。

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