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淋巴细胞活化基因-3的分子特征及药物研究进展
作者:吴曌娴  徐燕丽 
单位:南京医科大学附属南京医院/南京市第一医院 血液科, 江苏 南京 210006
关键词:淋巴细胞激活因子3 免疫细胞 药物治疗 文献综述 
分类号:R392.9
出版年·卷·期(页码):2021·49·第六期(704-709)
摘要:

淋巴细胞活化基因3(LAG-3)是一类免疫抑制性受体,可通过结合程序性细胞死亡受体(PD-1)对T细胞功能产生负调控,从而调节PD-1的耗尽状态。LAG-3可是一种潜在的癌症免疫治疗药物靶标,而现如今对于LAG-3的认识仍不足。本文就LAG-3的分子特征、与免疫细胞的关系以及LAG-3的药物研究现状作一综述。

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