Objective: To explore neutrophil CD64, Procalcitonin(PCT), and C-reactive protein(CRP) for the early clinical diagnosis of sepsis in children.Methods: A retrospective analysis was conducted, 80 confirmed pediatric sepsis children were allocated into sepsis group from September 2019 to September 2020, 89 healthy children were recruited as the control group. CD64 was detected by Flow cytometry, serum PCT was detected by chemiluminescence, and immunofluorescence method was used to detect serum CRP.Results: The age and gender distribution was not statistically different between the two groups(P>0.05); CD64, PCT, and CRP of children in the sepsis group were higher than those of the control group(P<0.05); CD64, PCT, and CRP were significantly positively correlated with each other; receiver operating characteristic(ROC) curve showed that the sensitivity and specificity of CD64 were better than PCT and CRP for early the diagnosis of neonatal sepsis in children. The area under the curve(AUC) value was also significantly higher than that of PCT and CRP(Z=5.27, P<0.001; Z=5.64, P<0.001). Conclusion: CD64 is a better diagnostic biomarker for early diagnosis of neonatal sepsis in children as compared to PCT and CRP.
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