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MYC基因在人肿瘤中致癌作用的泛癌分析
作者:王恒  赵春 
单位:江苏省中医院 检验科, 江苏 南京 210029
关键词:MYC 基因突变 磷酸化 预后分析 免疫浸润 
分类号:R34
出版年·卷·期(页码):2021·49·第八期(877-883)
摘要:

目的:研究MYC基因在人肿瘤组织内的基因及蛋白表达,并探讨其临床意义。方法:对TCGA和GEO数据库进行深入挖掘,观察MYC基因在肿瘤组织中的表达情况,并分析其与肿瘤预后的关系、发生突变情况、磷酸化水平以及免疫浸润和相关通路的情况。结果:MYC基因在多种肿瘤组织中的表达升高,表达的高低关系到不同类型肿瘤患者的预后,在卵巢癌、子宫肉瘤和食管癌患者中MYC的突变率最高,在乳腺浸润癌、卵巢癌和结肠癌中MYC的磷酸化水平更高,在不同肿瘤中MYC的表达与免疫浸润呈相关性,MYC可能通过“RNA转录”和“细胞周期”的通路参与了肿瘤的发生。结论:MYC在不同的肿瘤中都有表达,MYC的功能机制与蛋白质加工和RNA代谢密切相关。

Objective: To explore the oncogenic roles of MYC in tumors based on the database of TCGA(The cancer genome atlas) and GEO(Gene expression omnibus).Methods: We tried to research the associations between MYC expression and prognosis,genetic alteration, phosphorylation level, immune infiltration and gene enrichment pathway of tumor.Results: MYC was highly expressed in most ofcancers,the level of MYC expression is related to the prognosis of patients with different types of tumors.We observed the genetic alteration status of MYC in different tumor samples, the highest alteration frequency of MYC appeard in patients with ovarian serous cystadenocarcinoma, uterine carcinosarcoma and esophageal adenocarcinoma tumors. We compared the differences of MYC phosphorylation levels between normal tissues and primary tumor tissues. MYC exhibitedhigher phosphorylation level in breast invasive carcinoma,ovarian serous cystadenocarcinoma and colon adenocarcinoma tumor tissues compared with the normal tissues.we observed a statistical positive correlation of MYC expression and the infiltration value of cancer-associated fibroblasts for the tumors."RNA transcription" and "cell cycle" might be involved in the effect of MYC on tumor pathogenesis. Conclusions: MYC is expressed in differentcancers, whose functional mechanisms may be associated with protein processing and RNA metabolism.

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