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lncRNA GAS5和HOXA5在卵巢癌诊断和治疗中的应用前景
作者:王金凤  李静如  赵宏敏 
单位:哈尔滨医科大学附属第一医院 妇科, 黑龙江 哈尔滨 150007
关键词:卵巢癌 长链非编码RNA GAS5 同源框基因A5 综述 
分类号:R737.31
出版年·卷·期(页码):2022·50·第二期(259-263)
摘要:

卵巢癌是最常见的妇科肿瘤之一,病死率为47%,占妇科肿瘤的首位。卵巢癌早期症状不明显,大部分患者确诊即为中晚期,目前临床针对卵巢癌晚期患者治疗采用手术治疗以及铂和紫杉烷辅助治疗,但是由于卵巢癌患者容易化疗耐药及复发,5年生存率较低。目前临床上需要寻找卵巢癌的早期诊断标志物及最新的治疗方法。研究发现长链非编码RNA (lncRNA) GAS5在基因表达调控中发挥关键作用,同源框基因A5(HOXA5)在调节基因表达、细胞分化和机体形态的形成过程中同样起着重要作用,作者对LncRNA GAS5和HOXA5在卵巢癌诊断和治疗中的应用前景进行综述,为卵巢癌的早期诊断和治疗提供依据。

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