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类风湿关节炎滑膜成纤维细胞的表观遗传学研究进展
作者:宋彦 
单位:哈尔滨医科大学附属第二医院 风湿免疫科, 黑龙江 哈尔滨 150001
关键词:类风湿关节炎 滑膜成纤维细胞 表观遗传 综述 
分类号:R593.22;Q343
出版年·卷·期(页码):2022·50·第二期(263-267)
摘要:

类风湿关节炎(RA)是一种慢性自身免疫性疾病,其基本病理改变为滑膜炎。滑膜成纤维细胞(FLS)是关节滑膜衬里层的主要构成组分,并具有侵袭性表型的表观遗传印记特征,可促进RA的关节破坏。近年来,表观遗传学对RA FLS功能的影响越来越受到广泛关注,靶向FLS的治疗也为RA提供了新的治疗方向。作者综述表观遗传学在RA FLS中的研究进展,为RA的治疗提供个体化的思路。

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