不同溶媒稀释氯化钾口服液口感接受程度的效果观察-现代医学

不同溶媒稀释氯化钾口服液口感接受程度的效果观察

单位：1. 东南大学附属中大医院心血管内科, 江苏南京 210009;
2. 东南大学公共卫生学院, 江苏南京 210009

分类号：R472.9

出版年·卷·期（页码）：2022·50·第八期（1060-1063）

摘要：

目的：比较服用不同溶媒稀释的KCl口服液的口感接受程度。方法：健康受试者采用单盲，随机服用不同溶媒稀释的KCl口服液5 ml，记录其口感接受程度。配置方法对照组A：10%氯化钾(KCl)30 ml＋温水60 ml；改良组B：10% KCl 30 ml＋5%葡萄糖溶液(5% GS)60 ml；改良组C：10% KCl 30 ml＋10%葡萄糖溶液(10% GS)30 ml；改良组D：10% KCl 30 ml＋甜味剂1 g＋温水60 ml；改良组E：10% KCl 30 ml＋甜味剂2 g＋温水60 ml。结果：各组间评分均值比较，改良组D水平最高(78分)，改良组E其次(75分)，受试者口感接受程度各组间差异有统计学意义(F=40.667，P＜0.001)。对照组A与改良组B、C差异无统计学意义，与改良组D、E差异有统计学意义(P＜0.001)。改良组B、C分别与改良组D、E差异有统计学意义(P＜0.001)，但改良组B与C、改良组D与E差异无统计学意义。结论：临床上宜使用改良组D方法，分3次口服。无甜味剂时可以采用增加葡萄糖含量的方法配置，如10% KCl 30ml＋50% GS 20 ml(相当于1 g甜味剂甜度)＋温水40 ml。

Objective: To compare the mouthfeel acceptance of 10% potassium chloride injection diluted with different solvents.Methods: Healthy subjects were single-blind and randomly administered 5 ml of 10% potassium chloride injection diluted with different solvents,and their taste acceptance was recorded.Configuration method control group A was given 10% potassium chloride 30 ml added into 60 ml warm water;modified group B 10% potassium chloride 30 ml in 5% GS 60 ml;modified group C 10% potassium chloride 30 ml in 10% GS 30 ml;modified group D 10% potassium chloride 30 ml;modified group E 10% potassium chloride 30 ml in 60 ml warm water with 2 g+sweetener.Results: Compared with the average scores of other groups,the improved group D had the highest level (78 points),and the improved group E ranked the next (75 points).The taste acceptance level of the subjects had a statistically significant difference between the groups (F=40.667,P<0.001).There was no statistical significance between the control group A and the modified groups B and C,but there was statistical significance between the modified groups D and E (P<0.001).The group B and group C had statistical difference from groups D and E,repectively (P<0.001),but group B was not significantly different from group C,nor was group D from group E.Conclusion: Clinically,it is recommended to use the modified method of group D,orally in three doses.When there is no sweetener,increasing the glucose content can do the job as well,such as 10% potassium chloride 30 ml+50% GS 20 ml (equivalent to 1 g sweetener sweetness)+40 ml warm water.

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