PAR-2在鼻部气道炎症性疾病及哮喘中的研究进展-现代医学

PAR-2在鼻部气道炎症性疾病及哮喘中的研究进展

单位：1. 山西医科大学第一临床医学院, 山西太原 030001;
2. 山西医科大学第一医院耳鼻咽喉头颈外科, 山西太原 030001

分类号：R765;R562

出版年·卷·期（页码）：2022·50·第八期（1072-1076）

摘要：

呼吸道上皮是人体应对外界刺激因子，如烟雾、尘螨、细菌、病毒等的第一道屏障，在这些因子的刺激下可产生促炎细胞因子，导致气道内炎症细胞聚集、黏蛋白分泌和气道重塑，进而引起各种呼吸道疾病。近年来，丝氨酸蛋白酶在气道炎症疾病中的作用日益受到重视。蛋白酶激活受体-2(PAR-2)是胰蛋白酶、肥大细胞类胰蛋白酶和弹性蛋白酶等丝氨酸蛋白酶的受体，是一种G蛋白偶联受体，也是丝氨酸蛋白酶活性在细胞外的感受器，在人体中广泛表达，参与多种疾病的炎症反应。目前有多项研究表示PAR-2的激活与气道炎症性疾病有关。本文主要就PAR-2与气道炎症性疾病及哮喘的相关关系作一简要综述，期望能为呼吸系统疾病的治疗提供新的思路。

Respiratory epithelium is the first barrier for the human body to deal with external stimulating factors,such as smoke,dust mites,viruses,bacteria and so on.Under the stimulation of these factors,proinflammatory cytokines can be produced,resulting in the accumulation of inflammatory cells in the airway,mucin secretion and airway remodeling,which in turn lead to a variety of respiratory diseases.In recent years,more and more attention has been paid to the effect of serine protease in airway inflammatory diseases.PAR-2 is the receptor of serine protease such as trypsin,mast cell trypsin and elastase.It is a G protein coupled receptor and the extracellular receptor of serine protease activity.It is widely expressed in human body and participates in the inflammatory reaction of many diseases.At present,many studies have shown that the activation of PAR-2 is related to airway inflammatory diseases.This article mainly reviews the relationship between PAR-2 and airway inflammatory diseases and asthma,hoping to provide new ideas for the treatment of respiratory diseases.

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