[1] WEBER C, NOELS H.Atherosclerosis:current pathogenesis and therapeutic options[J].Nat Med, 2011, 17(11):1410-1422.
[2] YANG Y, LIU Y, WANG Y, et al.Regulation of SIRT1 and its roles in inflammation[J].Front Immunol, 2022, 13(1):1-16.
[3] 李显, 丁杰, 岑祥莹, 等.组蛋白赖氨酸特异性去甲基化酶1相互作用蛋白的研究进展[J].现代医学, 2020, 48(9):1224-1229.
[4] BEGUM M K, KONJA D, SINGH S, et al.Endothelial SIRT1 as a target for the prevention of arterial aging:promises and challenges[J].J Cardiovasc Pharmacol, 2021, 78(6):S63-S77.
[5] SHEN P, DENG X, CHEN Z, et al.SIRT1:a potential therapeutic target in autoimmune diseases[J].Front Immunol, 2021, 12(1):1-13.
[6] GROOTAERT M O, BENNETT M R.Sirtuins in atherosclerosis:guardians of healthspan and therapeutic targets[J].Nat Rev Cardiol, 2022, 22(3):1-16.
[7] BORRA M T, SMITH B C, DENU J M.Mechanism of human SIRT1 activation by resveratrol[J].J Biol Chem, 2005, 280(17):17187-17195.
[8] HISAHARA S, CHIBA S, MATSUMOTO H, et al.Transcriptional regulation of neuronal genes and its effect on neural functions:NAD-dependent histone deacetylase SIRT1(Sir2α)[J].J Pharmacol Sci, 2005, 98(3):200-204.
[9] KEMPER J K, CHOI S-E, KIM D H.Sirtuin 1 deacetylase:a key regulator of hepatic lipid metabolism[J].Vitam Horm, 2013, 91(1):385-404.
[10] KITAMURA Y I, KITAMURA T, KRUSE J-P, et al.FoxO1 protects against pancreatic β cell failure through NeuroD and MafA induction[J].Cell Metab, 2005, 2(3):153-163.
[11] ZHANG Q J, WANG Z, CHEN H Z, et al.Endothelium-specific overexpression of class III deacetylase SIRT1 decreases atherosclerosis in apolipoprotein E-deficient mice[J].Cardiovasc Res, 2008, 80(2):191-199.
[12] CHEN C J, YU W, FU Y-C, et al.Resveratrol protects cardiomyocytes from hypoxia-induced apoptosis through the SIRT1-FoxO1 pathway[J].Biochem Biophys Res Commun, 2009, 378(3):389-393.
[13] LING L, GU S, CHENG Y.Resveratrol inhibits adventitial fibroblast proliferation and induces cell apoptosis through the SIRT1 pathway[J].Mol Med Rep, 2017, 15(2):567-572.
[14] 王维蓉, 林蓉, 林琴琴, 等.非诺贝特通过Sirt1途径调控血管外膜成纤维细胞凋亡[J].中国动脉硬化杂志, 2011, 19(3):242.
[15] LUO J, NIKOLAEV A Y, IMAI S I, et al.Negative control of p53 by Sir2α promotes cell survival under stress[J].Cell, 2001, 107(2):137-148.
[16] CHEN W Y, WANG D H, YEN R C, et al.Tumor suppressor HIC1 directly regulates SIRT1 to modulate p53-dependent DNA-damage responses[J].Cell, 2005, 123(3):437-448.
[17] DU G, SONG Y, ZHANG T, et al.Simvastatin attenuates TNF-α-induced apoptosis in endothelial progenitor cells via the upregulation of SIRT1[J].Int J Mol Med, 2014, 34(1):177-182.
[18] MERCER J, BENNETT M.The role of p53 in atherosclerosis[J].Cell cycle, 2006, 5(17):1907-1909.
[19] MIALET-PEREZ J, VINDIS C.Autophagy in health and disease:focus on the cardiovascular system[J].Essays Biochem, 2017, 61(6):721-732.
[20] WANG L, XU C, JOHANSEN T, et al.SIRT1-a new mammalian substrate of nuclear autophagy[J].Autophagy, 2021, 17(2):593-595.
[21] YANG X, WEI J, HE Y, et al.SIRT1 inhibition promotes atherosclerosis through impaired autophagy[J].Oncotarget, 2017, 8(31):51447-51461.
[22] WILLIAMS L M, GILMORE T D.Looking down on NF-κB[J].Mol Cell Biol, 2020, 40(15):1-20.
[23] KAUPPINEN A, SUURONEN T, OJALA J, et al.Antagonistic crosstalk between NF-κB and SIRT1 in the regulation of inflammation and metabolic disorders[J].Cell Signal, 2013, 25(10):1939-1948.
[24] 余翠, 杨明, 陈忠.动脉粥样硬化中巨噬细胞极化及相关信号通路的研究进展[J].现代医学, 2019, 47(6):755-759.
[25] HAN J, TONG H-Q, CHENG S-Y, et al.Effect of kangshuanyihao formula on the inflammatory reaction and SIRT1/TLR4/NF-κB signaling pathway in endothelial injury[J].Evid Based Complement Alternat Med, 2017, 2017(1):1-11.
[26] HOSSEINI A M, MAJIDI J, BARADARAN B, et al.Toll-like receptors in the pathogenesis of autoimmune diseases[J].Adv Pharm Bull, 2015, 5(Suppl 1):605-614.
[27] WU B-W, WU M-S, LIU Y, et al.SIRT1-mediated deacetylation of NF-κB inhibits the MLCK/MLC2 pathway and the expression of ET-1, thus alleviating the development of coronary artery spasm[J].Am J Physiol Heart Circ Physiol, 2021, 320(1):458-468.
[28] QIAN L, MA L, WU G, et al.G004, a synthetic sulfonylurea compound, exerts anti-atherosclerosis effects by targeting SIRT1 in ApoE-/- mice[J].Vascul Pharmacol, 2017, 89(1):49-57.
[29] 杨蓉, 朱旭, 段智娟, 等.Sirt1抑制氧化型低密度脂蛋白诱导血管平滑肌细胞炎症反应[J].中华医学杂志, 2017, 97(21):1659-1663.
[30] KITADA M, KUME S, TAKEDA-WATANABE A, et al.Calorie restriction in overweight males ameliorates obesity-related metabolic alterations and cellular adaptations through anti-aging effects, possibly including AMPK and SIRT1 activation[J].Biochim Biophys Acta, 2013, 1830(10):4820-4827.
[31] DE KREUTZENBERG S V, CEOLOTTO G, PAPPARELLA I, et al.Downregulation of the longevity-associated protein sirtuin 1 in insulin resistance and metabolic syndrome:potential biochemical mechanisms[J].Diabetes, 2010, 59(4):1006-1015.
[32] HOWITZ K T, BITTERMAN K J, COHEN H Y, et al.Small molecule activators of sirtuins extend Saccharomyces cerevisiae lifespan[J].Nature, 2003, 425(1):191-196.
[33] HUBBARD B P, GOMES A P, DAI H, et al.Evidence for a common mechanism of SIRT1 regulation by allosteric activators[J].Science, 2013, 339(1):1216-1219.
[34] SHINMURA K, TAMAKI K, SANO M, et al.Caloric restriction primes mitochondria for ischemic stress by deacetylating specific mitochondrial proteins of the electron transport chain[J].Circ Res, 2011, 109(4):396-406.
[35] XIA N, DAIBER A, HABERMEIER A, et al.Resveratrol reverses endothelial nitric-oxide synthase uncoupling in apolipoprotein E knockout mice[J].J Pharmacol Exp Ther, 2010, 335(1):149-154.
[36] ZHANG Y, CAO X, ZHU W, et al.Resveratrol enhances autophagic flux and promotes Ox-LDL degradation in HUVECs via upregulation of SIRT1[J].Oxid Med Cell Longev, 2016, 2016(1):1-13.
[37] SANZ P.AMP-activated protein kinase:structure and regulation[J].Curr Protein Pept Sci, 2008, 9(5):478-492.
[38] CANTÓ C, GERHART-HINES Z, FEIGE J N, et al.AMPK regulates energy expenditure by modulating NAD+ metabolism and SIRT1 activity[J].Nature, 2009, 458(1):1056-1060.
[39] JIN X, CHEN M, YI L, et al.Delphinidin-3-glucoside protects human umbilical vein endothelial cells against oxidized low-density lipoprotein-induced injury by autophagy upregulation via the AMPK/SIRT1 signaling pathway[J].Mol Nutr Food Res, 2014, 58(10):1941-1951.
[40] THOMPSON A M, MARTIN K A, RZUCIDLO E M.Resveratrol induces vascular smooth muscle cell differentiation through stimulation of SirT1 and AMPK[J].PloS one, 2014, 9(1):e85495.
[41] BRASNYÓ P, MOLNÁR G A, MOHÁS M, et al.Resveratrol improves insulin sensitivity, reduces oxidative stress and activates the Akt pathway in type 2 diabetic patients[J].Br J Nutr, 2011, 106(3):383-389.
[42] XUE M, WEICKERT M O, QURESHI S, et al.Improved glycemic control and vascular function in overweight and obese subjects by glyoxalase 1 inducer formulation[J].Diabetes, 2016, 65(8):2282-2294.
[43] POURBAGHER-SHAHRI A M, FARKHONDEH T, ASHRAFIZADEH M, et al.Curcumin and cardiovascular diseases:focus on cellular targets and cascades[J].Biomed Pharmacother, 2021, 136(1):1-17.
[44] ZENDEDEL E, BUTLER A E, ATKIN S L, et al.Impact of curcumin on sirtuins:a review[J].J Cell Biochem, 2018, 119(12):10291-10300.
[45] LIN X-L, LIU M-H, HU H-J, et al.Curcumin enhanced cholesterol efflux by upregulating ABCA1 expression through AMPK-SIRT1-LXRα signaling in THP-1 macrophage-derived foam cells[J].DNA Cell Biol, 2015, 34(9):561-572.
[46] SUN Y, HU X, HU G, et al.Curcumin attenuates hydrogen peroxide-induced premature senescence via the activation of SIRT1 in human umbilical vein endothelial cells[J].Biol Pharm Bull, 2015, 38(8):1134-1141.
[47] GHAFOURI-FARD S, SHOOREI H, BAHROUDI Z, et al.Nrf2-related therapeutic effects of curcumin in different disorders[J].Biomolecules, 2022, 12(82):1-15.
[48] KRAJKA-KUNIAK V, PALUSZCZAK J, BAER-DUBOWSKA W.The Nrf2-ARE signaling pathway:an update on its regulation and possible role in cancer prevention and treatment[J].Pharmacol Rep, 2017, 69(3):393-402.
[49] YIN Y, WU X, PENG B, et al.Curcumin improves necrotising microscopic colitis and cell pyroptosis by activating SIRT1/NRF2 and inhibiting the TLR4 signalling pathway in newborn rats[J].Innate Immun, 2020, 26(7):609-617.
[50] SONG X, WANG L, FAN D.Insights into recent studies on biotransformation and pharmacological activities of ginsenoside Rd[J].Biomolecules, 2022, 12(4):1-34.
[51] KANG O J, KIM J S.Comparison of ginsenoside contents in different parts of Korean ginseng(Panax ginseng CA Meyer)[J].Prev Nutr Food Sci, 2016, 21(4):389.
[52] KIM J.Pharmacological and medical applications of Panax ginseng and ginsenosides:a review for use in cardiovascular diseases[J].J Ginseng Res, 2018, 42(3):264-269.
[53] ZHENG Z, WANG M, CHENG C, et al.Ginsenoside Rb1 reduces H2O2-induced HUVEC dysfunction by stimulating the sirtuin-1/AMP-activated protein kinase pathway[J].Mol Med Rep, 2020, 22(1):247-256.
[54] SHI G, LIU D, ZHOU B, et al.Ginsenoside Rb1 alleviates oxidative low-density lipoprotein-induced vascular endothelium senescence via the SIRT1/beclin-1/autophagy axis[J].J Cardiovasc Pharmacol, 2020, 75(2):155-167.
[55] KIM J-E, LEE W, YANG S, et al.Suppressive effects of rare ginsenosides, Rk1 and Rg5, on HMGB1-mediated septic responses[J].Food Chem Toxicol, 2019, 124(1):45-53.
[56] LEE Y Y, PARK J-S, LEE E-J, et al.Anti-inflammatory mechanism of ginseng saponin metabolite Rh3 in lipopolysaccharide-stimulated microglia:critical role of 5'-adenosine monophosphate-activated protein kinase signaling pathway[J].J Agric Food Chem, 2015, 63(13):3472-3480.
[57] CHENG B, GAO W, WU X, et al.Ginsenoside Rg2 ameliorates high-fat diet-induced metabolic disease through SIRT1[J].J Agric Food Chem, 2020, 68(14):4215-4226.
[58] HUANG Q, WANG T, YANG L, et al.Ginsenoside Rb2 alleviates hepatic lipid accumulation by restoring autophagy via induction of Sirt1 and activation of AMPK[J].Int J Mol Sci, 2017, 18(5):1-15.
[59] ZHU Y, YANG H, DENG J, et al.Ginsenoside Rg5 improves insulin resistance and mitochondrial biogenesis of liver via regulation of the Sirt1/PGC-1α signaling pathway in db/db mice[J].J Agric Food Chem, 2021, 69(30):8428-8439.
[60] BEHL T, SINGH S, SHARMA N, et al.Expatiating the pharmacological and nanotechnological aspects of the alkaloidal drug berberine:current and future trends[J].Molecules, 2022, 27(12):1-25.
[61] ZHU X, YANG J, ZHU W, et al.Combination of berberine with resveratrol improves the lipid-lowering efficacy[J].Int J Mol Sci, 2018, 19(12):1-10.
[62] SHAN Y, ZHANG S, GAO B, et al.Adipose tissue SIRT1 regulates insulin sensitizing and anti-inflammatory effects of berberine[J].Front Pharmacol, 2020, 11(1):1-15.
[63] ZHENG Y, KOU J, WANG P, et al.Berberine-induced TFEB deacetylation by SIRT1 promotes autophagy in peritoneal macrophages[J].Aging(Albany NY), 2021, 13(5):7096-7119.
[64] ZHANG H, SHAN Y, WU Y, et al.Berberine suppresses LPS-induced inflammation through modulating Sirt1/NF-κB signaling pathway in RAW264.7 cells[J].Int Immunopharmacol, 2017, 52(1):93-100.
[65] CHI L, PENG L, PAN N, et al.The anti-atherogenic effects of berberine on foam cell formation are mediated through the upregulation of sirtuin 1[J].Int J Mol Med, 2014, 34(4):1087-1093.
[66] PIRRO M, FRANCISCI D, BIANCONI V, et al.Nutraceutical Treatment for hypercholesterolemia in HIV-infected patients:the NU-TRY(HIV) randomized cross-over trial[J].Atherosclerosis, 2019, 280(1):51-57.
[67] OLAS B.Sea buckthorn as a source of important bioactive compounds in cardiovascular diseases[J].Food Chem Toxicol, 2016, 97(1):199-204.
[68] 王颖超, 柳茵, 刘维军, 等.沙棘黄酮对动脉粥样硬化大鼠血管的保护作用及机制[J].医学研究杂志, 2014, 43(1):90-93.
[69] PEREZ-VIZCAINO F, DUARTE J, ANDRIANTSITOHAINA R.Endothelial function and cardiovascular disease:effects of quercetin and wine polyphenols[J].Free Radic Res, 2006, 40(10):1054-1065.
[70] ZHOU Y, CAO Z Q, WANG H Y, et al.The anti-inflammatory effects of Morin hydrate in atherosclerosis is associated with autophagy induction through cAMP signaling[J].Mol Nutr Food Res, 2017, 61(9):1-10.
[71] TIAN S S, JIANG F S, ZHANG K, et al.Flavonoids from the leaves of Carya cathayensis Sarg.inhibit vascular endothelial growth factor-induced angiogenesis[J].Fitoterapia, 2014, 92(1):34-40.
[72] GATSIOU A, GEORGIOPOULOS G, VLACHOGIANNIS N I, et al.Additive contribution of microRNA-34a/b/c to human arterial ageing and atherosclerosis[J].Atherosclerosis, 2021, 327(1):49-58.
[73] 邢丽婉.山核桃叶总黄酮经miR-34a/SIRT1通路抗人脐静脉内皮细胞衰老的研究[D].杭州:浙江中医药大学, 2017.
[74] XU W, DENG Y Y, YANG L, et al.Metformin ameliorates the proinflammatory state in patients with carotid artery atherosclerosis through sirtuin 1 induction[J].Transl Res, 2015, 166(5):451-458. |
