Objective: To explore the relationship among anxiety-depression, sleep quality and quality of life in patients with inflammatory bowel disease (IBD), and to clarify main intervention direction of quality of life in patients with IBD. Methods: The subjects were 303 IBD patients who were hospitalized in the digestive department of a tertiary a-level hospital in Nanjing from July 2020 to February 2021. General information questionnaire, Pittsburgh sleep quality index(PSQI), hospital anxiety and depression scale (HADS) and inflammatory bowel disease questionnaire (IBDQ) were used to assess the general condition, sleep quality, anxiety-depression and quality of life. Results: The scores of sleep quality, anxiety-depression and life quality of IBD patients were 9(6,12), 10(6,15), 168(148,187), sleep quality was positively correlated with anxiety-depression(r=0.403, P<0.001), quality of life was negatively correlated with sleep quality anxiety-depression(r=0.405 and -0.754, P<0.001). The medicating effect test showed that sleep quality had a direct predictive effect on anxiety and depression (β=0.31, 95%CI 0.15-0.46, P<0.001), anxiety and depression had a direct negative effect on quality of life (β=-0.84, 95%CI -0.90--0.77, P=0.002), sleep quality had an indirect effect on quality of life (β=-0.26, 95%CI -0.39--0.13,P<0.001), the path coefficient between sleep quality and quality of life was not statistically significant (β=-0.09, 95%CI -0.14-0.03, P=0.061), which showed that anxiety-depression was a complete mediator between sleep quality and quality of life. Conclusion: Sleep quality affects life quality through a complete mediating effect of anxiety-depression. The clinical medical staff should focus on evaluating the sleep quality and anxiety-depression status of patients, and timely provide corresponding interventions to improve their quality of life. |
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