Objective: To analyze the correlation between food-specific IgG antibody and colorectal cancer(CRC), and to calculate the diagnostic efficacy combined with carcinoembryonic antigen(CEA) and carbohydrate antigen CA19-9 detection to determine whether food-specific IgG antibodies have predictive and diagnostic value for colorectal cancer.Methods: 30 patients were selected into cancer research group, 41 patients were selected into polyp inflammation group, and 35 people were selected into normal control group. The differences of age and sex in each group were analyzed. The difference of the total positive rate of food-specific IgG antibody in serum of each group were analyzed. The serum levels of 14 food-specific IgG antibodies in each group were compared. The serum CEA and CA19-9 levels of each group were compared. The potential diagnostic performance sex between single detection and combined testing was compared by subject operating characteristic curves to determine its diagnostic efficacy.Results: There were no statistically significant differences in age and gender sex between the three groups(64.10 and 19/11), (58.0 and 24/17) and(58.4 and 19/16) respectively. The total positive rate of food-specific IgG antibodies tested in the cancer study group, polyp inflammation group, and normal control group was 63.33%, 53.66%, and 31.43%, The difference was statistically significant. For 14 food-specific IgG antibodies levels compared between the three groups,differences of allergen existed in chicken, corn, crab, mushroom, rice, shrimp, beans and tomatoes(all P<0.05). The levels of CEA and CA19-9 in the three groups were compared(all P<0.001), showing statistically significant differences. However. After screening, we compared the performance of these five allergens of chicken, crab, mushroom, shrimp and tomato combined withCEA or CA19-9 or both. The combined diagnostic performance of seven items was better(AUC=0.925 0, Sensitivity=98.68%, Specificity=73.33%, Y1=0.720 2).Conclusion: The introduction of food-specific IgG antibody items combined with CEA and CA19-9 can improve the diagnostic efficiency of CRC. For people with food intolerance, avoiding allergenic foods may reduce the risk of CRC. |