年龄相关性黄斑变性(age related macular degeneration，AMD)，是发达国家65岁以上人群致盲的首要因素，在发展中国家的发病率也逐渐上升，然而其发病机制目前仍不明确。AMD的发病主要与衰老、氧化损伤、免疫炎症及新生血管生成等密切相关。microRNAs是一类编码长度约为22个核苷酸的非编码RNA，作为调节目的基因的重要分子，涉及细胞增殖、凋亡、代谢等多种活动，在阐明疾病的发病机制方面具有强大潜力。本文就近年来microRNAs在AMD的发生、发展阶段的调控机制进行综述。

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