Objective:To explore the risk factors affecting the prognosis of patients with sepsis. Methods: The clinical data of 208 patients with sepsis admitted to the Department of Intensive Care Unit of Chengdu Integrated Traditional Chinese and Western Medicine Hospital from January 2019 to December 2021 were retrospectively analyzed. Patients were divided into survival group(n=132) and death group(n=76) according to the clinical outcome when they were transferred out of ICU.The general information, vital signs within 24 hours of admission and the worst value of laboratory examination results of patients in the two groups were recorded;transfusion and intubation were recorded during ICU stay;Physiology and Chronic Health EvaluationⅡ(APACHEⅡ) score, Glasgow Coma Scale(GCS) score and Sequential Organ Failure Assessment(SOFA) score were calculated within 24 hours. Univariate analysis was performed on the indicators of the two groups, and multivariate Logistic regression analysis was performed to screen out the risk factors affecting the prognosis of patients with sepsis. Receiver operating characteristics(ROC) curve was drawn to analyze scores associated with outcome, and the predictive value of each score for death of sepsis patients was analyzed. Results: Age, female ratio, international normalized ratio(INR),creatinine(Cr),C-reactive protein(CRP), APACHEⅡ score, SOFA score, and endotracheal intubation ratio of patients in the death group were significantly higher than those in the survival group, while platelet(PLT) and GCS score were significantly lower than those in the survival group(P<0.05). Multivariate Logistic regression analysis showed that age, PLT, INR, CRP, GCS score, APACHEⅡ score, SOFA score were the prognostic factors of sepsis patients(P<0.05). ROC curve showed that the area under ROC curve(AUC) of SOFA score predicted the death of sepsis patients was 0.93, significantly higher than APACHEⅡ score(AUC=0.85, P=0.006 4) and GCS score(AUC=0.79, P=0.003). Conclusion: Age, APACHEⅡ score, PLT, INR, GCS score, CRP and SOFA score are prognostic factors in patients with sepsis.SOFA score has the highest predictive value for death in patients with sepsis, which is higher than APACHEⅡ score and GCS score. |
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