基于专利数据研究中药复方治疗哮喘的用药规律-现代医学

基于专利数据研究中药复方治疗哮喘的用药规律

单位：1. 南京中医药大学附属医院急诊科, 江苏南京 210029;
2. 南京中医药大学人工智能与信息技术学院, 江苏南京 210023

分类号：R562.25

出版年·卷·期（页码）：2023·51·第五期（575-582）

摘要：

目的：探索中国知网专利数据库中治疗哮喘的中药复方专利的用药规律。方法：检索中国知网专利数据库自建库至2022年7月11日收录的治疗哮喘的中药复方，对符合纳入标准复方中的药物进行频次、性味、归经以及功效分类统计分析,挖掘核心药物、药组及新处方。结果：共纳入中药复方406首，涉及中药1 005味，总的用药频次为5 270次。使用频次最高的中药依次为麻黄、甘草、杏仁、五味子、紫苏子等；药性以温、平、寒为主，药味以苦、辛、甘为主，多归于肺、脾、心经；药物功效以止咳化痰、补气、发散风寒为主。通过关联分析核心药对组合发现新方3首。结论：中药复方治疗哮喘以止咳化痰、泻肺平喘、温润肺气、补益脾肾、利水消肿为主要治法。核心药物的组合使用以及新药的挖掘可以为未来临床实践提供参考。

Objective: To explore the medication rules of Chinese herbal compounds for treating asthma based on the CNKI patent database. Methods: Chinese herbal compounds for treating asthma were searched in the CNKI patent database until July 11th, 2022.Statistical analysis was conducted on the frequency, taste, meridian and efficacy classification of the drugs that met the inclusion criteria in the compounds to discover core drugs, drug combinations and new prescriptions. Results: A total of 406 Chinese herbal compounds were included, involving 1 005 Chinese herbs, with a total medication frequency of 5 270 times. The Chinese herbs with the highest frequency of use were ranked as follows: Ephedra, Licorice, Apricot Kernel, Schisandra and Perilla Seed. The properties of the drugs were mainly warm, neutral and cold, while the tastes were mainly bitter, pungent, and sweet, with most of them belonging to the lung, spleen, and heart meridians. The drug efficacy was mainly focused on relieving cough and resolving phlegm, tonifying lung Qi, and dispelling wind and cold. Three new prescriptions were discovered with correlation analysis of core drugs. Conclusion: Chinese herbal compounds for treating asthma mainly focuses on relieving cough and resolving phlegm, promoting lung ventilation, tonifying lung Qi, nourishing spleen and kidney, and promoting diuresis and reducing swelling. The combined use of core drugs and the exploration of new drugs can provide references for future clinical practice.

参考文献：

[1] HUANG K,YANG T,XU J,et al.Prevalence,risk factors,and management of asthma in China:a national cross-sectional study[J].Lancet,2019,394(10196):407-418.
[2] 中华医学会呼吸病学分会哮喘学组.支气管哮喘防治指南(2020年版)[J].中华结核和呼吸杂志,2020,43(12):1023-1048.
[3] 王强,杨继,张垚,等.支气管哮喘中医全病程治疗方案中西医对照研究[J].辽宁中医杂志,2020,47(10):7-11.
[4] 国家药典委员会.中华人民共和国药典[M].北京:中国医药科技出版社，2020.
[5] 高学敏.中药学[M].北京:中国中医药出版社，2000.
[6] 唐仕欢,陈建新,杨洪军,等.基于复杂系统熵聚类方法的中药新药处方发现研究思路[J].世界科学技术(中医药现代化),2009,11(2):225-228.
[7] 林连美,田玉美,李云海,等.《金匮要略》痰饮咳嗽病篇有关条文析疑[J].国医论坛,2013,28(6):3-4.
[8] 李明华，殷凯生，蔡映云.哮喘病学[M].北京：人民卫生出版社，2005：57.
[9] 麦舒桃,韩云,李芳.《类证治裁》辨治喘证之要[J].辽宁中医药大学学报,2012,14(3):127-128.
[10] 唐学敏,魏小萌.《丹溪心法》学术思想浅析[J].陕西中医,2009,30(9):1245-1246,1269.
[11] 丁丽丽,施松善,崔健,等.麻黄化学成分与药理作用研究进展[J].中国中药杂志,2006(20):1661-1664.
[12] 张燕丽,孟凡佳,田园,等.炙甘草的化学成分与药理作用研究进展[J].化学工程师,2019,33(8):60-63,66.
[13] 赵玉升,胡杰,吴佳姝,等.苦杏仁炮制方法及药理作用研究进展[J].中医药导报,2021,27(3):175-180.
[14] 李晓光,高勤,翁文,等.五味子有效部位及其药理作用研究进展[J].中药材,2005(2):156-159.
[15] 马屏南.紫苏子镇咳、祛痰、平喘作用的药理研究[J].中国实用医药,2015,10(10):159-160.
[16] 王雪峰,高艳慧,王雪平,等.哮喘病机的中西医结合探析[J].中华中医药学刊,2008(3):469-470.
[17] 朱贤旬.华盖散治疗咳嗽变异性哮喘的临床效果[J].中国当代医药,2016,23(16):140-142.

服务与反馈：

【文章下载】【发表评论】【查看评论】【加入收藏】

提示：您还未登录，请登录！点此登录