低生糖指数饼干联合利拉鲁肽皮下注射对新发2型糖尿病肥胖患者糖脂代谢及体成分的影响-现代医学

低生糖指数饼干联合利拉鲁肽皮下注射对新发2型糖尿病肥胖患者糖脂代谢及体成分的影响

单位：1. 南京医科大学康达学院附属涟水人民医院, 江苏淮安 223400;
2. 淮安市中医院, 江苏淮安 223001

分类号：R587.1

出版年·卷·期（页码）：2023·51·第五期（583-589）

摘要：

目的：探讨低生糖指数(GI)饼干联合利拉鲁肽对新发2型糖尿病(T2DM)肥胖患者糖脂代谢及体成分的影响。方法：将新发T2DM肥胖患者90例随机分为低GI饼干组、利拉鲁肽组、低GI饼干联合利拉鲁肽组(联合干预组)3组。干预时间为6个月，测量干预期间3组患者肥胖、糖脂代谢和体成分等相关指标。结果：与低GI饼干组和利拉鲁肽组相比，联合干预组的腰臀比(WHR)、体质指数(BMI)、糖化血红蛋白(HbA1c)、甘油三酯(TG)、总胆固醇(TC)、低密度脂蛋白胆固醇(LDL-C)、高密度脂蛋白胆固醇(HDL-C)、空腹血糖(FPG)、胰岛素抵抗指数(HOMA-IR)、胰岛β细胞功能指数(HOMA-β)、体脂百分比、内脏脂肪面积等指标均有显著改善。结论：低GI饼干联合利拉鲁肽可改善新发T2DM肥胖患者肥胖、糖脂代谢和体成分。

Objective: To investigate the effects of low glycemic index(GI) biscuits combined with liraglutide on glucolipid metabolism and body composition in newly diagnosed type 2 diabetes mellitus(T2DM) patients with obesity. Methods: A total of 90 patients were randomly assigned into liraglutide group, low GI biscuits group, and low glycemic index(GI) biscuits combined with liraglutide group(combination group). The patients were followed up for 6 months. During the treatment, obesity, glucolipid metabolism, body composition and other clinical indicators were recorded. Results: Waist to hip ratio(WHR), body mass index(BMI), hemoglobin A1c(HbA1c), triglyceride(TG), total cholesterol(TC), low density lipoprotein cholesterol(LDL-C), high density lipoprotein cholesterol(HDL-C), fasting blood glucose(FPG), homeostasis model assessment of insulin resistance(HOMA-IR), homeostasis model assessment-β(HOMA-β), body fat percentage, visceral fat area were significantly improved in combination group compared with those in liraglutide group and low GI biscuits group. Conclusion: Low GI biscuits combined with liraglutide can improve glucolipid metabolism, obesity and body composition in newly diagnosed T2DM patients with obesity.

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