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肠神经递质对肠黏膜屏障的保护作用及其研究进展
作者:王非凡  郑骞  杜润森  李中信 
单位:河北医科大学第一医院 胃肠外科, 河北 石家庄 050031
关键词:肠神经递质 肠黏膜屏障 保护作用 文献综述 
分类号:R333.3
出版年·卷·期(页码):2023·51·第五期(707-712)
摘要:

肠黏膜屏障是机体抵御外界病原体最重要的屏障。肠神经递质作为肠神经系统中传递信息的“信使”,部分具有保护肠黏膜屏障的功能。作者对保护肠黏膜屏障的肠神经递质及保护的相关机制进行综述,为深入研究肠神经递质的功能以及其进一步临床应用提供理论基础。

参考文献:

[1] USUDA H,OKAMOTO T,WADA K.Leaky gut:effect of dietary fiber and fats on microbiome and intestinal barrier[J].Int J Mol Sci,2021,22(14):7613.
[2] CHOPYK D M,GRAKOUI A.Contribution of the intestinal microbiome and gut barrier to hepatic disorders[J].Gastroenterology,2020,159(3):849-863.
[3] MAGALHẪES H I R,CASTELUCCI P.Enteric nervous system and inflammatory bowel diseases:correlated impacts and therapeutic approaches through the P2X7 receptor[J].World J Gastroenterol,2021,27(46):7909-7924.
[4] FATTAHI F,STEINBECK J A,KRIKS S,et al.Deriving human ENS lineages for cell therapy and drug discovery in hirschsprung disease[J].Nature,2016,531(7592):105-109.
[5] SPENCER N J,HU H.Enteric nervous system:sensory transduction,neural circuits and gastrointestinal motility[J].Nat Rev Gastroenterol Hepatol,2020,17(6):338-351.
[6] GONKOWSKI S,RYTEL L.Somatostatin as an active substance in the mammalian enteric nervous system[J].Int J Mol Sci,2019,20(18):4461.
[7] YOU X Y,ZHANG H Y,HAN X,et al.Intestinal mucosal barrier is regulated by intestinal tract neuro-immune interplay[J].Front Pharmacol,2021,12:659716.
[8] JACOBSON A,YANG D,VELLA M,et al.The intestinal neuro-immune axis:crosstalk between neurons,immune cells,and microbes[J].Mucosal Immunol,2021,14(3):555-565.
[9] DHAWAN S,HIEMSTRA I H,VERSEIJDEN C,et al.Cholinergic receptor activation on epithelia protects against cytokine-induced barrier dysfunction[J].Acta Physiol(Oxf),2015,213(4):846-859.
[10] GREIG C J,COWLES R A.Muscarinic acetylcholine receptors participate in small intestinal mucosal homeostasis[J].J Pediatr Surg,2017,52(6):1031-1034.
[11] GUSTAFSSON J K,DAVIS J E,RAPPAI T,et al.Intestinal goblet cells sample and deliver lumenal antigens by regulated endocytic uptake and transcytosis[J].Elife,2021,10:e67292.
[12] YE Z,ZHU Y,TANG N,et al.α7 nicotinic acetylcholine receptor agonist GTS-21 attenuates DSS-induced intestinal colitis by improving intestinal mucosal barrier function[J].Mol Med,2022,28(1):59.
[13] LEI W,ZHAO C,SUN J,et al.Electroacupuncture ameliorates intestinal barrier destruction in mice with bile duct ligation-induced liver injury by activating the cholinergic anti-inflammatory pathway[J].Neuromodulation,2022,25(8):1122-1133.
[14] MIKAMI Y,TSUNODA J,KIYOHARA H,et al.Vagus nerve-mediated intestinal immune regulation:therapeutic implications of inflammatory bowel diseases[J].Int Immunol,2022,34(2):97-106.
[15] SINGH S P,CHAND H S,BANERJEE S,et al.Acetylcholinesterase inhibitor pyridostigmine bromide attenuates gut pathology and bacterial dysbiosis in a murine model of ulcerative colitis[J].Dig Dis Sci,2020,65(1):141-149.
[16] JOHNSON C D,BARLOW-ANACKER A J,PIERRE J F,et al.Deletion of choline acetyltransferase in enteric neurons results in postnatal intestinal dysmotility and dysbiosis[J].FASEB J,2018,32(9):4744-4752.
[17] LIGUZ-LECZNAR M,DOBRZANSKI G,KOSSUT M.Somatostatin and somatostatin-containing interneurons-from plasticity to pathology[J].Biomolecules,2022,12(2):312.
[18] DEL OLMO-GARCIA M I,PRADO-WOHLWEND S,ANDRES A,et al.Somatostatin and somatostatin receptors:from signaling to clinical applications in neuroendocrine neoplasms[J].Biomedicines,2021,9(12):1810.
[19] SHAMSI B H,CHATOO M,XU X K,et al.Versatile functions of somatostatin and somatostatin receptors in the gastrointestinal system[J].Front Endocrinol(Lausanne),2021,12:652363.
[20] STUEVEN A K,KAYSER A,WETZ C,et al.Somatostatin analogues in the treatment of neuroendocrine tumors:past,present and future[J].Int J Mol Sci,2019,20(12):3049.
[21] LI X,WANG Q,XU H,et al.Somatostatin regulates tight junction proteins expression in colitis mice[J].Int J Clin ExpPathol,2014,7(5):2153-2162.
[22] LI Y,LI X,GENG C,et al.Somatostatin receptor 5 is critical for protecting intestinal barrier function in vivo and in vitro[J].Mol Cell Endocrinol,2021,535:111390.
[23] EL SALHY M,HATLEBAKK J G.Changes in enteroendocrine and immune cells following colitis induction by TNBS in rats[J].Mol Med Rep,2016,14(6):4967-4974.
[24] LEVITE M.Neuropeptides,by direct interaction with T cells,induce cytokine secretion and break the commitment to a distinct T helper phenotype[J].Proc Natl Acad Sci U S A,1998,95(21):12544-12549.
[25] LIU L,TAN Q,HU B,et al.Somatostatin improved B cells mature in macaques during intestinal ischemia-reperfusion[J].PLoS One,2015,10(7):e0133692.
[26] SONG S,LI X,GENG C,et al.Somatostatin stimulates colonic MUC2 expression through SSTR5-Notch-Hes1 signaling pathway[J].Biochem Biophys Res Commun,2020,521(4):1070-1076.
[27] DELGADO M,GANEA D.Vasoactive intestinal peptide:a neuropeptide with pleiotropic immune functions[J].Amino Acids,2013,45(1):25-39.
[28] MORAMPUDI V,CONLIN V S,DALWADI U,et al.Vasoactive intestinal peptide prevents PKCε-induced intestinal epithelial barrier disruption during EPEC infection[J].Am J Physiol Gastrointest Liver Physiol,2015,308(5):G389-G402.
[29] SEO S,MIYAKE H,ALGANABI M,et al.Vasoactive intestinal peptide decreases inflammation and tight junction disruption in experimental necrotizing enterocolitis[J].J PediatrSurg,2019,54(12):2520-2523.
[30] YANG S,YU M.Role of goblet cells in intestinal barrier and mucosal immunity[J].J Inflamm Res,2021,14:3171-3183.
[31] YU H B,YANG H,ALLAIRE J M,et al.Vasoactive intestinal peptide promotes host defense against enteric pathogens by modulating the recruitment of group 3 innate lymphoid cells[J].Proc Natl Acad Sci U S A,2021,118(41):e2106634118.
[32] SONG X,PI S,GAO Y,et al.The role of vasoactive intestinal peptide and mast cells in the regulatory effect of lactobacillus casei ATCC 393 on intestinal mucosal immune barrier[J].Front Immunol,2021,12:723173.
[33] MARTÍNEZ C,JUARRANZ Y,GUTIÉRREZ-CAÑAS I,et al.A clinical approach for the use of VIP axis in inflammatory and autoimmune diseases[J].Int J Mol Sci,2019,21(1):65.
[34] SUN L J,LI J N,NIE Y Z.Gut hormones in microbiota-gut-brain cross-talk[J].Chin Med J(Engl),2020,133(7):826-833.
[35] FORTEA M,ALBERT-BAYO M,ABRIL-GIL M,et al.Present and future therapeutic approaches to barrier dysfunction[J].Front Nutr,2021,8:718093.
[36] CHANG Y,DENG Q,ZHANG Z,et al.Glucagon-like peptide 2 attenuates intestinal mucosal barrier injury through the MLCK/pMLC signaling pathway in a piglet model[J].J Cell Physiol,2021,236(4):3015-3032.
[37] MCCARTY M F,LERNER A.Perspective:prospects for nutraceutical support of intestinal barrier function[J].Adv Nutr,2021,12(2):316-324.
[38] CHEN X,ZHAO H X,FU X S,et al.Glucagonlike peptide 2 protects intestinal barrier in severe acute pancreatitis through regulating intestinal epithelial cell proliferation and apoptosis[J].Pancreas,2012,41(7):1080-1085.
[39] LEI Q,BI J,CHEN H,et al.Glucagon-like peptide-2 improves intestinal immune function and diminishes bacterial translocation in a mouse model of parenteral nutrition[J].Nutr Res,2018,49:56-66.
[40] CREMONINI E,DAVERI E,MASTALOUDIS A,et al.Anthocyanins protect the gastrointestinal tract from high fat diet-induced alterations in redox signaling,barrier integrity and dysbiosis[J].Redox Biol,2019,26:101269.
[41] WANG B,SUN S,LIU M,et al.Dietary l-tryptophan regulates colonic serotonin homeostasis in mice with dextran sodium sulfate-induced colitis[J].J Nutr,2020,150(7):1966-1976.
[42] WALLDORF J,PORZNER M,NEUMANN M,et al.The selective 5-HT1A agonist SR57746A protects intestinal epithelial cells and enteric glia cells and promotes mucosal recovery in experimental colitis[J].Inflamm Bowel Dis,2022,28(3):423-433.
[43] FUNG T C,VUONG H E,LUNA C D G,et al.Intestinal serotonin and fluoxetine exposure modulate bacterial colonization in the gut[J].Nat Microbiol,2019,4(12):2064-2073.
[44] ADAK A,KHAN M R.An insight into gut microbiota and its functionalities[J].Cell Mol Life Sci,2019,76(3):473-493.
[45] HAN C,GENG Q,QIN J,et al.Activation of 5-hydroxytryptamine 4 receptor improves colonic barrier function by triggering mucin 2 production in a mouse model of type 1 diabetes[J].Am J Pathol,2022,192(6):876-886.
[46] SAIA R S,RIBEIRO A B,GIUSTI H.Cholecystokinin modulates the mucosal inflammatory response and prevents the lipopolysaccharide-induced intestinal epithelial barrier dysfunction[J].Shock,2020,53(2):242-251.
[47] YU Y,YANG W,LI Y,et al.Enteroendocrine cells:sensing gut microbiota and regulating inflammatory bowel diseases[J].Inflamm Bowel Dis,2020,26(1):11-20.
[48] LUBBERS T,DE HAAN J J,LUYER M D,et al.Cholecystokinin/Cholecystokinin-1 receptor-mediated peripheral activation of the afferent vagus by enteral nutrients attenuates inflammation in rats[J].Ann Surg,2010,252(2):376-382.
[49] BATTY M J,CHABRIER G,SHERIDAN A,et al.Metabolic hormones modulate macrophage inflammatory responses[J].Cancers(Basel),2021,13(18):4661.
[50] ZHANG J G,LIU J X,JIA X X,et al.Cholecystokinin octapeptide regulates the differentiation and effector cytokine production of CD4(+) T cells in vitro[J].Int Immunopharmacol,2014,20(2):307-315.
[51] ARCINIEGA-MARTÍNEZ I M,RESÉNDIZ ALBOR A A,CÁRDENAS JARAMILLO L M,et al.CD4+/IL-4+ lymphocytes of the lamina propria and substance P promote colonic protection during acute stress[J].Mol Med Rep,2022,25(2):63.
[52] HONG H S,HWANG D Y,PARK J H,et al.Substance-P alleviates dextran sulfate sodium-induced intestinal damage by suppressing inflammation through enrichment of M2 macrophages and regulatory T cells[J].Cytokine,2017,90:21-30.
[53] ISHIOH M,NOZU T,IGARASHI S,et al.Activation of central adenosine A2B receptors mediate brain ghrelin-induced improvement of intestinal barrier function through the vagus nerve in rats[J].Exp Neurol,2021,341:113708.
[54] LI B,DOU Z,ZHANG L,et al.Ghrelin alleviates intestinal dysfunction in sepsis through the KLF4/MMP2 regulatory axis by activating SIRT1[J].Front Immunol,2021,12:646775.
[55] YUSTA B,BAGGIO L L,KOEHLER J,et al.GLP-1R agonists modulate enteric immune responses through the intestinal intraepithelial lymphocyte GLP-1R[J].Diabetes,2015,64(7):2537-2549.
[56] HOLST J J,ANDERSEN D B,GRUNDDAL K V.Actions of glucagon-like peptide-1 receptor ligands in the gut[J].Br J Pharmacol,2022,179(4):727-742.

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