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原癌基因Wip1与恶性肿瘤发生发展关系的研究进展
作者:张然  顾笑梅 
单位:华北理工大学, 河北 唐山 063000
关键词:野生型P53诱导的磷酸酶1 恶性肿瘤 基因表达 文献综述 
分类号:R730.2
出版年·卷·期(页码):2023·51·第五期(718-723)
摘要:

野生型p53诱导的磷酸酶1(Wip1)是一种依赖于p53的原癌基因,在神经母细胞瘤、乳腺癌、卵巢癌、胰腺癌、膀胱癌、肝癌、胃癌、大肠癌、甲状腺癌、髓母细胞瘤等恶性肿瘤中高表达,尤其与乳腺癌、胃癌及胰腺癌的发生、发展息息相关,但是其对肿瘤发生发展的调节机制尚不清楚。近年来Wip1抑制剂的研制成果不断有报道,作者综述了Wip1基因及其抑制剂在肿瘤中的表达以及Wip1基因与恶性肿瘤发生发展关系的研究进展,以期为恶性肿瘤的早期发现和治疗提供参考。

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