目的：通过检索近20年心血管疾病(CVD)中巨噬细胞极化的相关文献，可视化分析该领域的研究热点、前沿和趋势，旨在为未来该领域的基础和临床研究提供一定指导。方法：通过Web of Science数据库检索有关CVD中巨噬细胞极化的相关文章。利用CtieSpace和VOSviewer软件对该领域的国家、机构、作者、共被引文献和关键词进行可视化分析。结果：共纳入714篇文献。关于CVD中巨噬细胞极化的文章数量逐年显著增加。刊发这些文献的出版物主要来自以中国和美国为首的52个国家和330个机构。共发现4 382位作者，其中Merry L Lindsey的文章数最高，Gordon S的共被引频次最高。最常见的关键词是炎症、动脉粥样硬化、心肌梗死、心血管疾病、胰岛素抵抗、单核细胞、细胞和心力衰竭。潜在热点方面，近期爆发较强且仍在进行的关键词为基础动物实验研究、心脏修复、细胞凋亡。总结：在CVD领域中，巨噬细胞的研究正在蓬勃发展。其中基础动物实验研究、心脏修复和细胞凋亡将成为未来研究的重点。

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