[1] WU Z H,TANG Y,YU H,et al.The role of ferroptosis in breast cancer patients:a comprehensive analysis[J].Cell Death Discovery,2021,7(1):93.
[2] SHEN Z,LIU T,LI Y,et al.Fenton-reaction-acceleratable magnetic nanoparticles for ferroptosis therapy of orthotopic brain tumors[J].ACS Nano,2018,12(11):11355-11365.
[3] XU G,WANG H,LI X,et al.Recent progress on targeting ferroptosis for cancer therapy[J].Biochemical Pharmacology,2021,190:114584.
[4] MORALES M,XUE X.Targeting iron metabolism in cancer therapy[J].Theranostics,2021,11(17):8412-8429.
[5] CHEN X,KANG R,KROEMER G,et al.Broadening horizons:the role of ferroptosis in cancer[J].Nat Rev Clin Oncol,2021,18(5):280-296.
[6] CHEN P H,WU J,DING C K C,et al.Kinome screen of ferroptosis reveals a novel role of ATM in regulating iron metabolism[J].Cell Death and Differentiation,2020,27(3):1008-1022.
[7] NIETO C,VEGA M A,MARTIN D V E M.Tailored-made polydopamine nanoparticles to induce ferroptosis in breast cancer cells in combination with chemotherapy[J].Int J Mol Sci,2021,22(6):3161.
[8] DU J,WANG L,HUANG X,et al.Shuganning injection,a traditional Chinese patient medicine,induces ferroptosis and suppresses tumor growth in triple-negative breast cancer cells[J].Phytomedicine:International Journal of Phytotherapy and Phytopharmacology,2021,85:153551.
[9] TORTI S V,TORTI F M.Iron and cancer:2020 vision[J].Cancer Research,2020,80(24):5435-5448.
[10] MANZ D H,BLANCHETTE N L,PAUL B T,et al.Iron and cancer:recent insights[J].Ann N Y Acad of Sci,2016,1368(1):149-161.
[11] CHANG V C,COTTERCHIO M,BONDY S J,et al.Iron intake,oxidative stress-related genes and breast cancer risk[J].Int J Cancer,2020,147(5):1354-1373.
[12] PIZZAMIGLIO S,De BORTOLI M,TAVERNA E,et al.Expression of iron-related proteins differentiate non-cancerous and cancerous breast tumors[J].Int J Mol Sci,2017,18(2):410.
[13] FENG H,SCHORPP K,JIN J,et al.Transferrin receptor is a specific ferroptosis marker[J].Cell Reports,2020,30(10):3411-3423.e7.
[14] MARQUES O,ROSA A,LEITE L,et al.HFE variants and the expression of iron-related proteins in breast cancer-associated lymphocytes and macrophages[J].Cancer Microenviron,2016,9(2-3):85-91.
[15] CORTE-RODRIGUEZ M,BLANCO-GONZÁLEZ E,BETTMER J,et al.Quantitative analysis of transferrin receptor 1(TfR1) in individual breast cancer cells by means of labeled antibodies and elemental(ICP-MS) detection[J].Analytical Chemistry,2019,91(24):15532-15538.
[16] ASPERTI M,DENARDO A,GRYZIK M,et al.Pentosan polysulfate to control hepcidin expression in vitro and in vivo[J].Biochemical Pharmacology,2020,175:113867.
[17] BLANCHETTE F N,KITA D,KONSTORUM A,et al.Contribution of three-dimensional architecture and tumor-associated fibroblasts to hepcidin regulation in breast cancer[J].Oncogene,2018,37(29):4013-4032.
[18] LEFTIN A,BEN-CHETRIT N,JOYCE J A,et al.Imaging endogenous macrophage iron deposits reveals a metabolic biomarker of polarized tumor macrophage infiltration and response to CSF1R breast cancer immunotherapy[J].Scientific Reports,2019,9(1):857.
[19] DUAN X,HE K,LI J,et al.Tumor associated macrophages deliver iron to tumor cells via Lcn2[J].Int J Physiol,Pathophysiol Pharmacol,2018,10(2):105-114.
[20] BROWN C W,AMANTE J J,CHHOY P,et al.Prominin2 drives ferroptosis resistance by stimulating iron export[J].Developmental Cell,2019,51(5):575-586.e4.
[21] DIXON S J,LEMBERG K M,LAMPRECHT M R,et al.Ferroptosis:an iron-dependent form of nonapoptotic cell death[J].Cell,2012,149(5):1060-1072.
[22] YANG W S,STOCKWELL B R.Ferroptosis:death by lipid peroxidation[J].Trends in Cell Biology,2016,26(3):165-176.
[23] MAGTANONG L,KO P J,TO M,et al.Exogenous monounsaturated fatty acids promote a ferroptosis-resistant cell state[J].Cell Chemical Biology,2019,26(3):420-432.e9.
[24] ZANOAGA O,JURJ A,RADULY L,et al.Implications of dietary ω-3 and ω-6 polyunsaturated fatty acids in breast cancer[J].Exp Ther Med,2018,15(2):1167-1176.
[25] CHOI J,CHA Y J,KOO J S.Adipocyte biology in breast cancer:from silent bystander to active facilitator[J].Progress in Lipid Research,2018,69:11-20.
[26] LI H,LI L,XUE C,et al.A novel ferroptosis-related gene signature predicts overall survival of breast cancer patients[J].Biology,2021,10(2):151.
[27] DOLL S,PRONETH B,TYURINA Y Y,et al.ACSL4 dictates ferroptosis sensitivity by shaping cellular lipid composition[J].Nat Chem Biol,2017,13(1):91-98.
[28] ZHANG H L,HU B X,LI Z L,et al.PKCβ Ⅱ phosphorylates ACSL4 to amplify lipid peroxidation to induce ferroptosis[J].Nat Cell Biol,2022,24(1):88-98.
[29] BEATTY A,SINGH T,TYURINA Y Y,et al.Ferroptotic cell death triggered by conjugated linolenic acids is mediated by ACSL1[J].Nature Communications,2021,12(1):2244.
[30] ZOU Y,LI H,GRAHAM E T,et al.Cytochrome P450 oxidoreductase contributes tophospholipid peroxidation in ferroptosis[J].Nat Chem Biol,2020,16(3):302-309.
[31] DOLL S,REITAS F P,SHAH R,et al.FSP1 is a glutathione-independent ferroptosis suppressor[J].Nature,2019,575(7784):693-698.
[32] DAI E,ZHANG W,CONG D,et al.AIFM2 blocks ferroptosis independent of ubiquinol metabolism[J].Biochem Bioph Res Co,2020,523(4):966-971.
[33] ZHOU Y,YANG J,CHEN C,et al.Polyphyllin Ⅲ-induced ferroptosis in MDA-MB-231 triple-negative breast cancer cells can be protected against by KLF4-mediated upregulation of xCT[J].Frontiers in Pharmacology,2021,12:670224.
[34] ZHANG J,YANG J,ZUO T,et al.Heparanase-driven sequential released nanoparticles for ferroptosis and tumor microenvironment modulations synergism in breast cancer therapy[J].Biomaterials,2021,266:120429.
[35] ELAKKAD Y E,MOHAMED S N S,ABUELEZZ N Z.Potentiating the cytotoxic activity of a novel simvastatin-loaded cubosome against breast cancer cells:insights on dual cell death via ferroptosis and apoptosis[J].Breast Cancer(Dove Medical Press),2021,13:675-689.
[36] SEIBT T M,PRONETH B,CONRAD M.Role of GPX4 in ferroptosis and its pharmacological implication[J].Free Radical Biology Medicine,2019,133:144-152.
[37] SANTORO A L,DRUMMOND R D,SILVA I T,et al.In situ DESI-MSI lipidomic profiles of breast cancer molecular subtypes and precursor lesions[J].Cancer Research,2020,80(6):1246-1257.
[38] BEATTY A,FINK L S,SINGH T,et al.Metabolite profiling reveals the glutathione biosynthetic pathway as a therapeutic target in triple-negative breast cancer[J].Mol Cancer Ther,2018,17(1):264-275.
[39] XIONG H,WANG C,WANG Z,et al.Intracellular cascade activated nanosystem for improving ER+ breast cancer therapy through attacking GSH-mediated metabolic vulnerability[J].J Control Release,2019,309:145-157.
[40] LI X,ZHANG K,HU Y,et al.ERRα activates SHMT2 transcription to enhance the resistance of breast cancer to lapatinib via modulating the mitochondrial metabolic adaption[J].Bioscience Reports,2020,40(1):BSR20192465.
[41] SONG X,ZHU S,CHEN P,et al.AMPK-mediated BECN1 phosphorylation promotes ferroptosis by directly blocking system X(c)(-) activity[J].Current Biology,2018,28(15):2388-2399.e5.
[42] WANG W,GREEN M,CHOI J E,et al.CD8(+) T cells regulate tumour ferroptosis during cancer immunotherapy[J].Nature,2019,569(7755):270-274.
[43] LIU J,XIA X,HUANG P.xCT:acritical molecule that links cancer metabolism to redox signaling[J].Molecular Therapy,2020,28(11):2358-2366.
[44] JIANG Y,CAO Y,WANG Y,et al.Cysteine transporter SLC3A1 promotes breast cancer tumorigenesis[J].Theranostics,2017,7(4):1036-1046.
[45] LLABANI E,HICKLIN R W,LEE H Y,et al.Diverse compounds from pleuromutilin lead to a thioredoxin inhibitor and inducer of ferroptosis[J].Nature Chemistry,2019,11(6):521-532.
[46] CAO J,CHEN X,JIANG L,et al.DJ-1 suppresses ferroptosis through preserving the activity of S-adenosyl homocysteine hydrolase[J].Nature Communications,2020,11(1):1251. |
