[1] NUSSE R,VARMUS H E.Many tumors induced by the mouse mammary tumor virus contain a provirus integrated in the same region of the host genome[J].Cell,1982,31(1):99-109.
[2] NVSSLEIN-VOLHARD C,WIESCHAUS E.Mutations affecting segment number and polarity in Drosophila[J].Nature,1980,287(5785):795-801.
[3] NUSSE R,VAN OOYEN A,COX D,et al.Mode of proviral activation of a putative mammary oncogene(int-1) on mouse chromosome 15[J].Nature,1984,307(5947):131-136.
[4] NUSSE R,CLEVERS H.Wnt/β-catenin signaling,disease,and Emerging therapeutic modalities[J].Cell,2017,169(6):985-999.
[5] CLEVERS H,NUSSE R.Wnt/β-catenin signaling and disease[J].Cell,2012,149(6):1192-1205.
[6] KOMIYA Y,HABAS R.Wnt signal transduction pathways[J].Organogenesis,2008,4(2):68-75.
[7] CLEVERS H.Wnt/beta-catenin signaling in development and disease[J].Cell,2006,127(3):469-480.
[8] GILES R H,VAN ES J H,CLEVERS H.Caught up in a Wnt storm:Wnt signaling in cancer[J].Biochim Biophys Acta,2003,1653(1):1-24.
[9] MACDONALD B T,TAMAI K,HE X.Wnt/beta-catenin signaling:components,mechanisms,and diseases[J].Dev Cell,2009,17(1):9-26.
[10] HE T C,SPARKS A B,RAGO C,et al.Identification of c-MYC as a target of the APC pathway[J].Science,1998,281(5382):1509-1512.
[11] HERMANS K C,BLANKESTEIJN W M.Wnt signaling in cardiac disease[J].Compr Physiol,2015,5(3):1183-1209.
[12] KUMAWAT K,GOSENS R.WNT-5A:signaling and functions in health and disease[J].Cell Mol Life Sci,2016,73(3):567-587.
[13] VANDERVORST K,HATAKEYAMA J,BERG A,et al.Cellular and molecular mechanisms underlying planar cell polarity pathway contributions to cancer malignancy[J].Semin Cell Dev Biol,2018,81:78-87.
[14] KVHL M,SHELDAHL L C,MALBON C C,et al.Ca(2+)/calmodulin-dependent protein kinase Ⅱ is stimulated by Wnt and Frizzled homologs and promotes ventral cell fates in Xenopus[J].J Biol Chem,2000,275(17):12701-12711.
[15] LANG C M R,CHAN C K,VELTRI A,et al.Wnt signaling pathways in keratinocyte carcinomas[J].Cancers(Basel),2019,11(9):1216.
[16] SCHULTE G.International union of basic and clinical pharmacology.LXXX.The class Frizzled receptors[J].Pharmacol Rev,2010,62(4):632-667.
[17] LEE S,KANG J,CHO M,et al.Profiling of transcripts and proteins modulated by K-ras oncogene in the lung tissues of Kras transgenic mice by omics approaches[J].Int J Oncol,2009,34(1):161-172.
[18] PACHECO-PINEDO E C,DURHAM A C,STEWART K M,et al.Wnt/β-catenin signaling accelerates mouse lung tumorigenesis by imposing an embryonic distal progenitor phenotype on lung epithelium[J].J Clin Invest,2011,121(5):1935-1945.
[19] HE B,YOU L,UEMATSU K,et al.A monoclonal antibody against Wnt-1 induces apoptosis in human cancer cells[J].Neoplasia,2004,6(1):7-14.
[20] LEMJABBAR-ALAOUI H,VAN ZANTE A,SINGER M S,et al.Sulf-2,a heparan sulfate endosulfatase,promotes human lung carcinogenesis[J].Oncogene,2010,29(5):635-646.
[21] MALANCHI I,SANTAMARIA-MARTíNEZ A,SUSANTO E,et al.Interactions between cancer stem cells and their niche govern metastatic colonization[J].Nature,2011,481(7379):85-89.
[22] HUANG C L,LIU D,ISHIKAWA S,et al.Wnt1 overexpression promotes tumour progression in non-small cell lung cancer[J].Eur J Cancer,2008,44(17):2680-2688.
[23] NAKASHIMA N,LIU D,HUANG C L,et al.Wnt3 gene expression promotes tumor progression in non-small cell lung cancer[J].Lung Cancer,2012,76(2):228-234.
[24] HOMMURA F,FURUUCHI K,YAMAZAKI K,et al.Increased expression of beta-catenin predicts better prognosis in nonsmall cell lung carcinomas[J].Cancer,2002,94(3):752-758.
[25] ZHENG H,SAITO H,MASUDA S,et al.Phosphorylated GSK3beta-ser9 and EGFR are good prognostic factors for lung carcinomas[J].Anticancer Res,2007,27(5b):3561-3569.
[26] REGAD T.Molecular and cellular pathogenesis of melanoma initiation and progression[J].Cell Mol Life Sci,2013,70(21):4055-4065.
[27] VANCE K W,GODING C R.The transcription network regulating melanocyte development and melanoma[J].Pigment Cell Res,2004,17(4):318-325.
[28] RUBINFELD B,ROBBINS P,EL-GAMIL M,et al.Stabilization of beta-catenin by genetic defects in melanoma cell lines[J].Science,1997,275(5307):1790-1792.
[29] HARTMAN M L,SZTILLER-SIKORSKA M,GAJOS-MICHNIEWICZ A,et al.Dissecting mechanisms of melanoma resistance to BRAF and MEK inhibitors revealed genetic and non-genetic patient-and drug-specific alterations and remarkable phenotypic plasticity[J].Cells,2020,9(1):142.
[30] CHIEN A J,HAYDU L E,BIECHELE T L,et al.Targeted BRAF inhibition impacts survival in melanoma patients with high levels of Wnt/β-catenin signaling[J].PLoS One,2014,9(4):e94748.
[31] Cancer Genome Atlas Network.Comprehensive molecular characterization of human colon and rectal cancer[J].Nature,2012,487(7407):330-337.
[32] MORIN P J,SPARKS A B,KORINEK V,et al.Activation of beta-catenin-Tcf signaling in colon cancer by mutations in beta-catenin or APC[J].Science,1997,275(5307):1787-1790.
[33] SURAWEERA N,ROBINSON J,VOLIKOS E,et al.Mutations within Wnt pathway genes in sporadic colorectal cancers and cell lines[J].Int J Cancer,2006,119(8):1837-1842.
[34] YANG A D,FAN F,CAMP E R,et al.Chronic oxaliplatin resistance induces epithelial-to-mesenchymal transition in colorectal cancer cell lines[J].Clin Cancer Res,2006,12(14 Pt 1):4147-4153.
[35] SPEARS E,NEUFELD K L.Novel double-negative feedback loop between adenomatous polyposis coli and Musashi1 in colon epithelia[J].J Biol Chem,2011,286(7):4946-4950.
[36] DOW L E,O'ROURKE K P,SIMON J,et al.Apc restoration promotes cellular differentiation and reestablishes crypt homeostasis in colorectal cancer[J].Cell,2015,161(7):1539-1552.
[37] WAISBERG J,SABA G T.Wnt-/-β-catenin pathway signaling in human hepatocellular carcinoma[J].World J Hepatol,2015,7(26):2631-2635.
[38] DING S L,YANG Z W,WANG J,et al.Integrative analysis of aberrant Wnt signaling in hepatitis B virus-related hepatocellular carcinoma[J].World J Gastroenterol,2015,21(20):6317-6328.
[39] SCHULZE K,IMBEAUD S,LETOUZÉ E,et al.Exome sequencing of hepatocellular carcinomas identifies new mutational signatures and potential therapeutic targets[J].Nat Genet,2015,47(5):505-511.
[40] NEJAK-BOWEN K N,THOMPSON M D,SINGH S,et al.Accelerated liver regeneration and hepatocarcinogenesis in mice overexpressing serine-45 mutant beta-catenin[J].Hepatology,2010,51(5):1603-1613.
[41] HUANG G L,LUO Q,RUI G,et al.Oncogenic activity of retinoic acid receptor γ is exhibited through activation of the Akt/NF-κB and Wnt/β-catenin pathways in cholangiocarcinoma[J].Mol Cell Biol,2013,33(17):3416-3425.
[42] ZHENG L,SUN D,FAN W,et al.Diagnostic value of SFRP1 as a favorable predictive and prognostic biomarker in patients with prostate cancer[J].PLoS One,2015,10(2):e0118276.
[43] WU L,ZHAO J C,KIM J,et al.ERG is a critical regulator of Wnt/LEF1 signaling in prostate cancer[J].Cancer Res,2013,73(19):6068-6079.
[44] BAUMAN T M,VEZINA C M,RICKE E A,et al.Expression and colocalization of β-catenin and lymphoid enhancing factor-1 in prostate cancer progression[J].Hum Pathol,2016,51:124-133.
[45] DAKHOVA O,ROWLEY D,ITTMANN M.Genes upregulated in prostate cancer reactive stroma promote prostate cancer progression in vivo[J].Clin Cancer Res,2014,20(1):100-109.
[46] SUN Y,CAMPISI J,HIGANO C,et al.Treatment-induced damage to the tumor microenvironment promotes prostate cancer therapy resistance through WNT16B[J].Nat Med,2012,18(9):1359-1368.
[47] 张皓渝,刘红兵,刘卫华,等.Wnt/β-catenin信号通路在胃癌中的研究进展[J].中国现代普通外科进展,2021,24(9):721-724.
[48] YODA Y,TAKESHIMA H,NIWA T,et al.Integrated analysis of cancer-related pathways affected by genetic and epigenetic alterations in gastric cancer[J].Gastric Cancer,2015,18(1):65-76.
[49] CAI C,ZHU X.The Wnt/β-catenin pathway regulates self-renewal of cancer stem-like cells in human gastric cancer[J].Mol Med Rep,2012,5(5):1191-1196.
[50] TEEUWSSEN M,FODDE R.Wnt signaling in ovarian cancer stemness,EMT,and therapy resistance[J].J Clin Med,2019,8(10):1658.
[51] ZHANG C,ZHANG Z,ZHANG S,et al.Targeting of Wnt/β-catenin by anthelmintic drug pyrvinium enhances sensitivity of ovarian cancer cells to chemotherapy[J].Med Sci Monit,2017,23:266-275.
[52] XU X,ZHANG M,XU F,et al.Wnt signaling in breast cancer:biological mechanisms,challenges and opportunities[J].Mol Cancer,2020,19(1):165.
[53] VAN SCHIE E H,VAN AMERONGEN R.Aberrant WNT/CTNNB1 signaling as a therapeutic target in human breast cancer:weighing the evidence[J].Front Cell Dev Biol,2020,8:25.
[54] SÄFHOLM A,TUOMELA J,ROSENKVIST J,et al.The Wnt-5a-derived hexapeptide Foxy-5 inhibits breast cancer metastasis in vivo by targeting cell motility[J].Clin Cancer Res,2008,14(20):6556-6563.
[55] 冯晓灵,刘丹.白头翁皂苷D对人乳腺癌MCF-7细胞中Wnt/β-链蛋白信号通路的影响[J].东南大学学报(医学版),2017,36(3):379-383.
[56] GRUSZKA A M,VALLI D,ALCALAY M.Wnt signalling in acute myeloid leukaemia[J].Cells,2019,8(11):1403.
[57] SIMON M,GRANDAGE V L,LINCH D C,et al.Constitutive activation of the Wnt/beta-catenin signalling pathway in acute myeloid leukaemia[J].Oncogene,2005,24(14):2410-2420.
[58] YSEBAERT L,CHICANNE G,DEMUR C,et al.Expression of beta-catenin by acute myeloid leukemia cells predicts enhanced clonogenic capacities and poor prognosis[J].Leukemia,2006,20(7):1211-1216.
[59] YANG D H,YOON J Y,LEE S H,et al.Wnt5a is required for endothelial differentiation of embryonic stem cells and vascularization via pathways involving both Wnt/beta-catenin and protein kinase Calpha[J].Circ Res,2009,104(3):372-379.
[60] SARZANI R,SALVI F,BORDICCHIA M,et al.Carotid artery atherosclerosis in hypertensive patients with a functional LDL receptor-related protein 6 gene variant[J].Nutr Metab Cardiovasc Dis,2011,21(2):150-156.
[61] CHRISTMAN M A,GOETZ D J,DICKERSON E,et al.Wnt5a is expressed in murine and human atherosclerotic lesions[J].Am J Physiol Heart Circ Physiol,2008,294(6):H2864-2870.
[62] MALGOR R,BHATT P M,CONNOLLY B A,et al.Wnt5a,TLR2 and TLR4 are elevated in advanced human atherosclerotic lesions[J].Inflamm Res,2014,63(4):277-285.
[63] UELAND T,OTTERDAL K,LEKVA T,et al.Dickkopf-1 enhances inflammatory interaction between platelets and endothelial cells and shows increased expression in atherosclerosis[J].Arterioscler Thromb Vasc Biol,2009,29(8):1228-1234.
[64] ZHANG M,HAGENMUELLER M,RIFFEL J H,et al.Calcium/calmodulin-dependent protein kinase II couples Wnt signaling with histone deacetylase 4 and mediates dishevelled-induced cardiomyopathy[J].Hypertension,2015,65(2):335-344.
[65] ZHOU J,AHMAD F,PARIKH S,et al.Loss of adult cardiac myocyte GSK-3 leads to mitotic catastrophe resulting in fatal dilated cardiomyopathy[J].Circ Res,2016,118(8):1208-1222.
[66] HOSSINI A M,MEGGES M,PRIGIONE A,et al.Induced pluripotent stem cell-derived neuronal cells from a sporadic Alzheimer's disease donor as a model for investigating AD-associated gene regulatory networks[J].BMC Genomics,2015,16(1):84.
[67] VIDAL R,GARRO-MARTÍNEZ E,DÍAZ Á,et al.Targeting β-catenin in GLAST-expressing cells:impact on anxiety and depression-related behavior and hippocampal proliferation[J].Mol Neurobiol,2019,56(1):553-566.
[68] BUECHLER J,SALINAS P C.Deficient Wnt signaling and synaptic vulnerability in Alzheimer's disease:emerging roles for the LRP6 receptor[J].Front Synaptic Neurosci,2018,10:38.
[69] CARICASOLE A,COPANI A,CARACI F,et al.Induction of Dickkopf-1,a negative modulator of the Wnt pathway,is associated with neuronal degeneration in Alzheimer's brain[J].J Neurosci,2004,24(26):6021-6027.
[70] TIWARI S K,AGARWAL S,SETH B,et al.Curcumin-loaded nanoparticles potently induce adult neurogenesis and reverse cognitive deficits in Alzheimer's disease model via canonical Wnt/β-catenin pathway[J].ACS Nano,2014,8(1):76-103.
[71] NOURI N,PATEL M J,JOKSIMOVIC M,et al.Excessive Wnt/beta-catenin signaling promotes midbrain floor plate neurogenesis,but results in vacillating dopamine progenitors[J].Mol Cell Neurosci,2015,68:131-142.
[72] INESTROSA N C,ARENAS E.Emerging roles of Wnts in the adult nervous system[J].Nat Rev Neurosci,2010,11(2):77-86.
[73] L'EPISCOPO F,TIROLO C,TESTA N,et al.Wnt/β-catenin signaling is required to rescue midbrain dopaminergic progenitors and promote neurorepair in ageing mouse model of Parkinson's disease[J].Stem Cells,2014,32(8):2147-2163.
[74] ALTARCHE-XIFRO W,DI VICINO U,MUÑOZ-MARTIN M I,et al.Functional rescue of dopaminergic neuron loss in Parkinson's disease mice after transplantation of hematopoietic stem and progenitor cells[J].EBioMedicine,2016,8:83-95.
[75] HAMMAD H,LAMBRECHT B N.Wnt and Hippo pathways in regulatory T cells:a NOTCH above in asthma[J].Nat Immunol,2020,21(11):1313-1314.
[76] KUMAWAT K,KOOPMANS T,GOSENS R.β-catenin as a regulator and therapeutic target for asthmatic airway remodeling[J].Expert Opin Ther Targets,2014,18(9):1023-1034.
[77] QU J,YUE L,GAO J,et al.Perspectives on Wnt signal pathway in the pathogenesis and therapeutics of chronic obstructive pulmonary disease[J].J Pharmacol Exp Ther,2019,369(3):473-480.
[78] CARLIER F M,DUPASQUIER S,AMBROISE J,et al.Canonical WNT pathway is activated in the airway epithelium in chronic obstructive pulmonary disease[J].EBioMedicine,2020,61:103034.
[79] WANG Y,FREEDMAN J A,LIU H,et al.Associations between RNA splicing regulatory variants of stemness-related genes and racial disparities in susceptibility to prostate cancer[J].Int J Cancer,2017,141(4):731-743.
[80] SANDSMARK E,HANSEN A F,SELNæS K M,et al.A novel non-canonical Wnt signature for prostate cancer aggressiveness[J].Oncotarget,2017,8(6):9572-9586.
[81] LI L,DU Z,GAO Y,et al.PLCε knockdown overcomes drug resistance to androgen receptor antagonist in castration-resistant prostate cancer by suppressing the wnt3a/β-catenin pathway[J].J Cell Physiol,2019,234(9):15472-15486.
[82] GAO S,YU Y,LIU L,et al.Circular RNA hsa_circ_0007059 restrains proliferation and epithelial-mesenchymal transition in lung cancer cells via inhibiting microRNA-378[J].Life Sci,2019,233:116692. |
