OSAHS患者血清可溶性髓样细胞触发受体2水平的变化及其意义-现代医学

OSAHS患者血清可溶性髓样细胞触发受体2水平的变化及其意义

单位：如皋市人民医院呼吸与危重症医学科, 江苏南通 226500

分类号：R563.9

出版年·卷·期（页码）：2023·51·第十期（1423-1427）

摘要：

目的：检测阻塞性睡眠呼吸暂停低通气综合征（OSAHS）患者血清可溶性髓样细胞触发受体2（sTREM2）水平并探讨其临床意义。方法：选取在我院门诊和住院接受多导睡眠（PSG）监测的人群作为受试者，根据睡眠呼吸暂停低通气指数（AHI）将受试者分为OSAHS组61例（AHI≥5次·h^-1）和对照组30例（AHI<5次·h^-1）。根据蒙特利尔认知评估（MoCA）将OSAHS组分成认知功能正常（MoCA得分≥26分，41例）和合并轻度认知功能障碍（MCI）（MoCA得分<26分，20例）。采用ELISA法测定所有受试者的血清sTREM2的含量。结果：OSAHS组患者的血清sTREM2水平较对照组升高（P<0.05），且与认知功能正常的OSAHS患者相比，合并MCI的OSAHS患者血清sTREM2水平更高（P<0.05）。OSAHS患者的sTREM2水平受MoCA评分、平均血氧饱和度（MSaO₂）和血氧饱和度低于90%的时间占总监测时间的百分比（TS90%）的影响，MoCA评分、MSaO₂较低且TS90%较高的OSAHS患者血清sTEM2水平可能更高。结论：OSAHS患者血清sTREM2水平升高，尤其是合并MCI的患者。因此，血清sTREM2水平有可能成为OSAHS患者MCI的生物标志物。

Objective: This study aimed to compare serum levels of soluble triggering receptor expresses on myeloid cells 2(sTREM2) in normal individuals and patients with obstructive sleep apnea-hypopnea syndrome(OSAHS). Methods: People who received polysomnography(PSG) monitoring in our hospital were selected as subjects. According to the sleep apnea-hypopnea index(AHI), the subjects were divided into OSAHS group(AHI ≥ 5 times·h^-1,n=61) and control group(AHI<5 times·h^-1, n=30). According to the Montreal cognitive assessment(MoCA) score,the patients of OSAHS group were divided into the normal cognitive function(MoCA ≥ 26 points, n=41) and the mild cognitive impairment(MCI)(MoCA<26 points,n=20). The serum STREM2 content was determined by ELISA in all subjects. Results: OSAHS group had higher serum sTREM2 levels than the control group(P<0.05). Additionally, serum sTREM2 levels were higher in OSAHS patients with MCI(P<0.05). Multivariate linear regression analysis showed that serum sTREM2 levels in patients with OSAHS were associated with the MoCA score, MSaO₂ and TS90% levels. OSAHS Patients with low MoCA scores, low MSaO₂, and higher TS90% may have higher serum sTEM2 levels. Conclusion: Serum sTREM2 levels are elevated in patients with OSAHS, especially those with MCI. Therefore, serum sTREM2 levels have the potential to become biomarker of MCI in OSAHS patients.

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