西安某医院4 618名体检人群骨质疏松患病率及相关因素分析-现代医学

西安某医院4 618名体检人群骨质疏松患病率及相关因素分析

单位：西安交通大学第二附属医院, 陕西西安 710004

分类号：R681

出版年·卷·期（页码）：2023·51·第十一期（1604-1610）

摘要：

目的：调查西安某医院健康体检人群骨质疏松(OP)患病率及相关因素分析，为OP防治提供参考依据。方法：选择2020年1月至12月在西安交通大学第二附属医院健康体检部进行健康体检的人群，排除继发性OP及其他影响骨代谢因素，共纳入研究对象4 618例。按照骨密度(BMD)分为骨量(BM)正常、BM减少、OP 3组，并根据性别、月经情况分为不同亚组。分析年龄、体重指数(BMI)、血压、空腹血糖(FBG)、血脂等与骨密度的相关性。结果：OP总体患病率为17.65%，OP组的年龄、BMI、收缩压(SBP)、舒张压(DBP)、空腹血糖(FBG)和血脂高于BM正常和BM减少组，甘油三酯(TG)在3组中无明显差异。男性人群OP患病率为12.94%，OP组年龄和SBP高于BM正常和BM减少组；FBG和血脂水平无明显差异；女性人群OP患病率为23.40%，OP组年龄、BMI、SBP、DBP、FBG、总胆固醇(TC)、TG、低密度脂蛋白胆固醇(LDL-C)均高于BM正常和BM减少组，高密度脂蛋白胆固醇(HDL-C)无明显差异；绝经前女性OP患病率为6.25%，OP组BMI、SBP、DBP均高于BM正常和BM减少组；绝经后女性OP患病率为43.23%，OP组年龄、SBP高于BM正常和BM减少组。多因素Logistic回归分析显示，男性、绝经前及绝经后女性中，SBP均提示为BMD降低的危险因素。结论：本研究人群OP患病率为17.65%，其中男性人群为12.94%，女性人群为23.40%(绝经前女性为6.25%，绝经后女性为43.23%)。BMD与BMI、FBG、血压、血脂等有关，不同亚群可能有不同的易感性。

Objective: To investigate the prevalence of osteoporosis(OP) and the related factors among the people in a hospital in Xi'an, and to provide reference for the prevention and treatment of OP. Methods: A total of4 618 people who underwent physical examination in the Physical Examination Department of the Second Affiliated Hospital of Xi'an Jiaotong University from January 2020 to December 2020 were enrolled in this study, excluding secondary OP and other factors affecting bone metabolism. They were divided into three groups according to bone mineral density(BMD), i.e., normal bone mass, decreased bone mass and OP groups. At the same time, they were subgrouped according to sex and menstrual status. The correlation between age, BMI, blood pressure, fasting blood glucose(FBG), blood lipids and BMD was analyzed. Results: The results showed that the overall prevalenceof osteoporosis in the study population was 17.65%. The age, body mass index(BMI), systolic blood pressure(SBP), diastolic blood pressure(DBP), FBG, and blood lipids of the OP group were higher than those of the normal and decreased bone mass groups, and there was no significant difference in triglycerides(TG)among the three groups. The prevalence of OP in the male population was 12.94%, and the age and SBP in the OP group were higher than those in the normal and decreased bone mass groups. There was no significant difference in FBG and blood lipid. The prevalence of OP in the female population was 23.40%. The age, BMI, SBP, DBP, FBG, total cholesterol(TC), TG, and low-density lipoprotein-cholesterol(LDL-C) in OP group were higher than those in the normal and decreased bone mass groups, and there was no significant difference in high-density lipoprotein cholesterol(HDL-C). The prevalence of OP in premenopausal women was 6.25%. The BMI, SBP and DBP of the OP group were higher than those of the normal and decreased bone mass groups. The prevalenceof OP in postmenopausal women was 43.23%. The age and SBP of the OP group were higher than those of the normal and decreased bone mass groups. Multivariate Logistic regression analysis showed that SBP was a risk factor for decreased BMD in men, premenopausal and postmenopausal women.Conclusion: The prevalence of OP in this study population is 17.65%, with 12.94% in males and 23.40% in females(6.25% in premenopausal women and 43.23% in postmenopausal women). BMD is related to BMI, FBG, blood pressure, blood lipids, etc. Different subgroups may have different susceptibility.

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