垂体混合瘤在临床中相对罕见，本文报道1例以肢端肥大症和中枢性甲亢为主要临床表现的病例，最终诊断为垂体促甲状腺激素(TSH)、生长激素(GH)混合侵袭性巨腺瘤。该患者术前接受生长抑素受体配体辅助治疗使垂体瘤缩小，然后于神经外科接受了经蝶窦垂体瘤切除术且辅助生长抑素受体配体治疗后，患者垂体及靶腺激素水平恢复正常。本文回顾性分析垂体TSH、GH混合瘤案例的诊疗过程,并通过查阅、复习文献，总结其临床表现、治疗方案及结局，提高临床医生对此病的认识，以期提高治疗效果。

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