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类器官在乳腺癌中的研究进展
作者:孙清  石欣  张亚男  吕建鑫 
单位:东南大学附属中大医院 普通外科, 江苏 南京 210000
关键词:乳腺癌 类器官 个体化治疗 肿瘤模型 乳腺癌机制 综述 
分类号:R737.9;R730.5
出版年·卷·期(页码):2023·51·第十二期(1788-1792)
摘要:

乳腺癌已成为中国妇女发病率最高的肿瘤,其发病率呈逐年增高趋势,为女性健康的重大隐患。因此,实现乳腺癌患者的个体化治疗尤为重要。乳腺癌类器官是一种利用患者癌组织干细胞进行体外培养的三维模型,能够保持原发肿瘤异质性和肿瘤生长的微环境,在疾病建模、肿瘤发生机制和药敏试验等方面提供了可靠的模型。本文概述了乳腺癌类器官的基础、机制研究、药敏试验及新药研发等方面,为乳腺癌的个体化治疗提供新的方向。

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