他汀类药物与阿司匹林联合应用在心血管疾病治疗中的有效性和安全性：一项基于随机对照试验的Meta分析-现代医学

他汀类药物与阿司匹林联合应用在心血管疾病治疗中的有效性和安全性：一项基于随机对照试验的Meta分析

单位：1. 海南省老年病医院药剂科, 海南海口 571100;
2. 海南医学院第一附属医院药学部, 海南海口 570102

分类号：R714.252

出版年·卷·期（页码）：2024·52·第二期（222-230）

摘要：

目的：探究他汀类药物和阿司匹林联合应用在心血管疾病治疗中的有效性和安全性。方法：检索PubMed、CNKI等数据库建库至2022年12月12日间他汀类药物和阿司匹林联合应用治疗心血管疾病的随机对照试验，按照纳排标准对文献进行筛选，基于Cochrane 5.1.0评估偏倚风险、Review Manager 5.4软件进行文献质量评价和Meta分析。结果：共纳入文献26篇，Meta分析结果表明，他汀类药物与阿司匹林联用可显著降低患者心血管疾病发作率(WMD=0.13，95%CI 0.11~0.14，P＜0.001)、心血管疾病死亡率(WMD=2.98，95%CI 0.18~5.79，P＜0.001)和血清总胆固醇(WMD=0.91，95%CI 0.20~1.62，P=0.01)、低密度脂蛋白胆固醇(WMD=0.92，95%CI 0.22~1.61，P=0.01)、高密度脂蛋白胆固醇水平(WMD=0.66，95%CI 0.09~1.22，P=0.02)，降低药物不良反应发生率(WMD=10.29，95%CI 7.09~13.48，P＜0.001)。结论：他汀类药物和阿司匹林联合应用对心血管疾病的治疗具有一定优势，值得临床推广应用。

Objective: To investigate the efficacy and safety of statins combined with aspirin in the treatment of cardiovascular diseases. Methods: Randomized controlled clinical trials on the combination of statins and aspirin for cardiovascular diseases was retrievaled in PubMed and CNKI from the establishment of the database to December 12,2022.The literature was screened according to the inclusion and exclusion criteria.The risk of bias was evaluated based on Cochrane 5.1.0, literature quality evaluation and Meta-analysis were conducted using Review Manager 5.4 software. Results: Twenty-six relevant papers were included, and the Meta-analysis results showed that the combination of statins and aspirin significantly reduced the patients cardiovascular disease exacerbation(WMD=0.13, 95%CI 0.11-0.14, P＜0.001), cardiovascular disease mortality(WMD=2.98, 95%CI 0.18-5.79, P＜0.001) and serum total cholesterol(WMD =0.91, 95%CI 0.20-1.62, P=0.01), lowdensity lipoprotein(LDL) cholesterol(WMD=0.92, 95%CI 0.22-1.61, P=0.010), high density lipoprotein(HDL) cholesterol levels(WMD=0.66, 95%CI 0.21-1.61, P=0.01). 95%CI 0.09-1.22, P=0.02), and reduced the incidence of adverse drug reactions(WMD=10.29, 95%CI 7.09-13.48, P＜0.001). Conclusion: The combination of statins and aspirin has certain advantages in the treatment of cardiovascular diseases and is worthy of clinical promotion.

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