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肺癌免疫治疗相关肺炎生物标志物的研究进展
作者:田雨1  陆元花2  赵沛妍3  李慧3  程颖3 4 
单位:1. 长春中医药大学 临床医学院, 吉林 长春 130012;
2. 吉林省肿瘤医院 博士后工作站, 吉林 长春 130012;
3. 吉林省肿瘤医院 肿瘤转化医学实验室, 吉林 长春 130012;
4. 吉林省肿瘤医院 内一科, 吉林 长春 130012
关键词:免疫治疗相关肺炎 肺癌 免疫治疗 生物标志物 综述 
分类号:R563.1; R730.6
出版年·卷·期(页码):2024·52·第三期(492-498)
摘要:

近年来免疫治疗极大地改善了晚期肺癌患者的生存,但是免疫治疗引发的不良反应也逐步凸显。免疫治疗相关肺炎(CIP)是免疫治疗引发的严重肺损伤,在肺癌中发生率高于其他肿瘤,是导致肺癌患者免疫治疗停药甚至死亡的重要因素。在接受免疫治疗的肺癌患者中通过生物标志物进行预测及实时监测有助于CIP的提前预防、尽早诊断和及时干预,这对肺癌患者的管理和治疗具有重要意义,但目前尚无应用于临床的CIP生物标志物。本文参考国内外相关CIP生物标志物的探索研究进行系统综述,以期对寻找具有临床价值的CIP生物标志物提供依据,为减少肺癌患者免疫治疗副反应的发生提供参考。

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