目的： 分析既往研究中精准输血对输血结局的影响，并与本院通过Rh表型数据库管理达到的精准输血进行比较，为建立Rh表型数据库的必要性提供临床理论和实践依据。方法： 检索并统计现有报道中关于Rh表型输血的文献数据，根据异质性检验结果采用固定效应或随机效应模式荟萃分析Rh表型匹配的精准输血与普通ABO-Rh D配合输血比较所造成的不同输血结局。对本院临床患者(受血者)血样和献血者(供血者)样本进行ABO血型以及Rh C、c、D、E、e抗原表型鉴定，鉴定结果录入输血管理系统中并建立Rh血型系统5种抗原表型数据库。分别统计两院区的精准输血率以及不规则抗体产生率和输血不良反应发生率。将文献数据统计的结果与本院比较，分析建立Rh表型数据库对精准输血的优势。结果： 荟萃分析文献数据结果纳入4个结局，分别为不规则抗体产生率、不规则抗体类型分布、输血不良反应发生率和输血前后血红蛋白升高量。结果显示，精准输血组不规则抗体产生率(MD=0.41,95%CI 0.36~0.46,P＜0.001)、不规则抗体中Rh系统所占比例(MD=0.46,95%CI 0.36~0.60,P＜0.001)、输血不良反应发生率(MD=0.33,95%CI 0.16~0.70,P=0.004)均较普通输血组低，差异有统计学意义。精准输血组输血后血红蛋白升高量明显高于普通输血组，差异有统计学意义(MD=8.37,95%CI 5.22~11.53,P＜0.001)。试验时段扬州大学附属医院东院区用血1 448 U，精准输血例数635例，占东院区总输血例数的77.5%；西院区用血3 500 U，精准输血例数1 626例，占西院区总输血例数的82.3%。与文献统计结果比较，本院使用Rh表型数据库管理的输血结局中，输血不良反应发生率与精准输血组相近，较普通输血组明显降低，差异有统计学意义(P<0.05)。不规则抗体阳性率较文献结果中精准输血组、普通输血组均明显降低，差异有统计学意义(P＜0.05)。结论： 建立Rh表型数据库可以促进Rh抗原的精准匹配，有利于精准输血从而降低同种异体免疫的风险。

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