三羧酸循环代谢物与老年人代谢综合征相关性分析-现代医学

三羧酸循环代谢物与老年人代谢综合征相关性分析

单位：安徽医科大学公共卫生学院, 安徽合肥 230032

分类号：R589

出版年·卷·期（页码）：2025·53·第七期（1115-1120）

摘要：

目的：探讨血清三羧酸(TCA)循环代谢物与老年人代谢综合征(MetS)的相关性。方法：本研究为横断面研究，选取2016年6月至9月在安徽省六安市收集的1 020名年龄≥60周岁老年人的问卷调查和体格检查数据，并利用气相色谱-串联质谱法检测血清中TCA循环代谢物水平。根据MetS诊断标准将数据进行分组，采用卡方检验、Mann-Whitney U检验和二元Logistic回归模型探讨TCA循环代谢物与MetS之间的关系。结果：在血清TCA靶标代谢物中，有6个代谢物水平在MetS组与非MetS组中的差异具有统计学意义(P<0.05)。与低分位组相比，高分位组的异柠檬酸(OR=0.581，95%CI 0.418~0.809)、α-酮戊二酸(OR=0.565，95%CI 0.410~0.778)、延胡索酸(OR=0.684，95%CI 0.479~0.976)和苹果酸(OR=0.635，95%CI 0.461~0.874)分别是MetS风险保护因素；而高分位组的柠檬酸/异柠檬酸比值(OR=1.740，95%CI 1.250~2.423)和琥珀酸/异柠檬酸比值(OR=1.868，95%CI 1.342~2.600)是MetS危险因素。结论：高水平的异柠檬酸、α-酮戊二酸、延胡索酸和苹果酸与老年人MetS发生风险降低相关；而高水平的柠檬酸/异柠檬酸和琥珀酸/异柠檬酸比值与老年人MetS发生风险升高相关。

Objective:To investigate the correlations between serum tricarboxylic acid(TCA) cycle metabolites and metabolic syndrome(MetS) in the elderly.Methods:This was a cross-sectional study, data were collected from questionnaires and physical examinations of 1 020 older adults aged ≥60 years conducted in Lu'an City, Anhui Province, from June to September 2016. Using gas chromatography-tandem mass spectrometry to detect TCA cycle metabolite levels in serum. Then participants were grouped according to the diagnostic criteria for MetS. Chi-square test, Mann-Whitney U test, and binary logistic regression models were used to investigate the association between TCA cycle metabolites and MetS. Results:Six targeted TCA cycle metabolite indicators showed statistically significant differences between the MetS and non-MetS groups(P<0.05). Compared with the low-quartile group, the high quartile groups of isocitrate(OR=0.581, 95%CI 0.418-0.809), α-ketoglutarate(OR=0.565, 95%CI 0.410-0.778), fumarate(OR=0.684, 95%CI 0.479-0.976), and malate(OR=0.635, 95%CI 0.461-0.874) were protective factors for MetS risk. However, the citrate/isocitrate ratio(OR=1.740, 95%CI 1.250-2.423) and succinate/isocitrate ratio(OR=1.868, 95%CI 1.342-2.600) in the high tertile groups were risk factors for MetS. Conclusion:High levels of isocitrate, α-ketoglutarate, fumarate, and malate were associated with a reduced risk of MetS in the elderly, whereas high levels of citrate/isocitrate and succinate/isocitrate ratios were associated with an elevated risk of MetS.

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