人多效蛋白对肺癌早期诊断的价值-现代医学

人多效蛋白对肺癌早期诊断的价值

单位：东南大学临床医学院; 东南大学附属中大医院核医学科;

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出版年·卷·期（页码）：2009·37·第四期（249-252）

摘要：

目的评价肿瘤标志物多效蛋白(PTN)对肺癌早期诊断的价值。方法采用特异性酶联免疫吸附试验对11例小细胞肺癌(SCLC)及50例非小细胞肺癌(NSCLC)的血清PTN水平进行检测,并与17例肺部良性病变及10例健康者进行比较。结果PTN在健康者血清中微量存在;在肺部良性病变、NSCLC及SCLC患者的血清中浓度呈梯度上升,差异均具有统计学意义(均P<0.01)。血清PTN对SCLC灵敏度、特异度分别达90.9%和94.1%。结论PTN是一种有效检测肺癌的标志物,尤其在SCLC的血清中升高更明显,因此血清PTN可作为早期诊断SCLC的指标。

Objective To evaluate the diagnostic value of the tumor marker of pleiotrophin(PTN) in patients with lung cancer.Methods The levels of PTN was measured by enzyme-linked immunosorbent assay(ELISA) in serum of 11 patients with small cell lung cancer(SCLC),48 patients with non-small cell lung cancer(NSCLC),17 patients with benign lung lesion disease and 10 healthy controls.Results A low amount of PTN can be measured in healthy controls.The levels of PTN in patients with benign lung disease,NSCLC and SCLC were ...

参考文献：

[1]	Courty J, Dauchel MC, Caruelle D, et al. Mitogenic properties of a new endothelial cell growth factor related to pleiotrophin .Biochem Biophys Res Commun, 1991, 180 :145-151 .
[2]	Li YS, Milner P G, Chauhan AK, et al. Cloning and expressin of a developmentally regulated protein that induces mitogenic and neurite outgrowth activity .Science, 1990, 250 :1690-1694 .
[3]	Wu,H,Barusevicius,A,Babb,J,Klein-Szanto,AK,Godwin,A,Elentsas,R,Gelfand,JM,Lessin,S,Seykora,JT. Pleiotrophin expression correlates with melanocytic tumor progression and metastatic potential .J Cutan Pathol, 2005, 32 :125~130 .
[4]	Tong Y,Mentlein R,Buhl R,et al. Overexpression of midkine con-tributes to anti-apoptotic effects in human meningiomas .J Neuro-chem, 2007, 100 (4) :1097-1107 .
[5]	Yeh HS,Chen H,Manyak SJ,et al. Serum pleiotrophin levels are elevated in multiple myeloma patients and correlate with disease status[J] .Br J Haematol, 2006, 133 (5) :526-529 .
[6]	Milner PG, Li YS, Hoffman RM, et al. A novel 17 kDa heparin-binding growth factor (HBGF-8) in bovine uterus: purification and N-terminal amino acid sequence .Biochem Biophys Res Commun, 1989, 165 :1096-1103 .
[7]	Souttou B, Juhl H, Hackenbruck J, et al. Relationship between serum concentrations of the growth factor pleiotrophin and pleiotrophin-positive tumors .J Natl Cancer Inst, 1998, 90(19) :1468-1473 .
[8]	Jager,R,List,B,Knabbe,C,Souttou,B,Raulais,D,Zeiler,T,Wellstein,A,Aigner,A,Neubauer,A,Zugmaier,G. Serum levels of the angiogenic factor pleiotrophin in relation to disease stage in lung cancer patients .Br J Cancer, 2002, 86 :858~863 .
[9]	Calvet L,Geoerger B,Regairaz M,et al. Pleiotrophin,acandidate gene for poor tumor vasculature andin vivoneuroblastoma sensitivity to irinotecan[J] .Oncogene, 2006, 25 (22) :3150-3159 .
[10]	Klomp H J,Zernial O,Flachmann S,et al. Significance of theexpression of the growth factor pleiotrophin in pancreatic cancerpatients[J] .Clin Cancer Res, 2002, 8 (3) :823-827 .

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